Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.30 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.30 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | ABL1 | P00519 | 1/20 | 0.30 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.30 |
| ▸ | FYN | P06241 | 1/20 | 0.30 |
| ▸ | CSF1R | P07333 | 1/20 | 0.30 |
| ▸ | RET | P07949 | 1/20 | 0.30 |
| ▸ | IGF1R | P08069 | 1/20 | 0.30 |
| ▸ | MET | P08581 | 1/20 | 0.30 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.30 |
| ▸ | PIM1 | P11309 | 1/20 | 0.30 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.30 |
| ▸ | PRKACA | P17612 | 1/20 | 0.30 |
| ▸ | LTK | P29376 | 1/20 | 0.30 |
| ▸ | GRK5 | P34947 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6283334 | 0.83 | PTPN1 (0.40) | PTPN1EGFRCHEK1AURKADAPK3 | |
| SCHEMBL10434845 | 0.80 | PTPN1 (0.38) | PTPN1EGFRCHEK1AURKADAPK3 | |
| SCHEMBL9901198 | 0.79 | PTPN1 (0.37) | PTPN1EGFRCHEK1AURKADAPK3 | |
| SCHEMBL3163121 | 0.78 | PTPN1 (0.36) | PTPN1EGFRNPC1CHEK1AURKA | |
| SCHEMBL9901394 | 0.77 | PTPN1 (0.38) | PTPN1EGFR | |
| SCHEMBL2048597 | 0.74 | EGFR (0.41) | PTPN1EGFR | |
| SCHEMBL12855014 | 0.74 | PTPN1 (0.41) | PTPN1EGFRCHEK1AURKADAPK3 | |
| SCHEMBL3903483 | 0.73 | PDCD1 (0.44) | PTPN1EGFRCHEK1AURKADAPK3 | |
| SCHEMBL30566658 | 0.73 | PTPN1 (0.46) | PTPN1EGFRCHEK1AURKADAPK3 | |
| SCHEMBL1135286 | 0.72 | PTPN1 (0.39) | PTPN1EGFRCHEK1AURKADAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2852589-A1 | TRIAZOLES AS KV3 INHIBITORS | Autifony Therapeutics Limited (GB) | 2015-04-01 | — | — | EP | disclosed |
| WO-2013175215-A1 | TRIAZOLES AS KV3 INHIBITORS | AUTIFONY THERAPEUTICS LIMITED (GB) | 2013-11-28 | — | — | WO | disclosed |