Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6283334 | 0.90 | PTPN1 (0.40) | PTPN1GABRA1EGFRCHEK1AURKA | |
| SCHEMBL10434845 | 0.87 | PTPN1 (0.38) | PTPN1GABRA1GABRB2L3MBTL1MAPT | |
| SCHEMBL9901198 | 0.79 | PTPN1 (0.37) | PTPN1L3MBTL1EGFRCHEK1AURKA | |
| SCHEMBL27655777 | 0.78 | L3MBTL1 (0.58) | PTPN1L3MBTL1MAPTNPSR1EGFR | |
| SCHEMBL13791138 | 0.77 | PTPN1 (0.44) | PTPN1GABRA1GABRB2L3MBTL1MAPT | |
| SCHEMBL2048597 | 0.77 | EGFR (0.41) | PTPN1L3MBTL1MAPTNPSR1EGFR | |
| SCHEMBL27655748 | 0.77 | L3MBTL1 (0.38) | PTPN1L3MBTL1MAPTNPSR1HPGD | |
| SCHEMBL9901394 | 0.76 | PTPN1 (0.38) | PTPN1EGFRALOX5PTGS2KDM4E | |
| SCHEMBL8973829 | 0.76 | L3MBTL1 (0.40) | PTPN1GABRA1GABRB2L3MBTL1MAPT | |
| SCHEMBL30566658 | 0.76 | PTPN1 (0.46) | PTPN1L3MBTL1EGFRCHEK1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2195322-B1 | IMIDAZO[1,2-A]PYRIMIDINE DERIVATIVES FOR TREATING DISEASES SUCH AS DIABETES | MERCK PATENT GMBH (DE) | 2014-08-06 | — | — | EP | disclosed |
| US-8278312-B2 | Imidazo 1,2-a pyrimidine derivatives for the treatment of diseases such as diabetes | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 2012-10-02 | — | — | US | disclosed |
| US-8278312-B2 | Imidazo 1,2-a pyrimidine derivatives for the treatment of diseases such as diabetes | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 2012-10-02 | — | — | US | disclosed |
| US-20100249151-A1 | IMIDAZO 1, 2-A PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF DISEASES SUCH AS DIABETES | Merck Patent Gesellschaft Beschrankter Haftung (DE) | 2010-09-30 | — | — | US | disclosed |
| US-20100249151-A1 | IMIDAZO 1, 2-A PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF DISEASES SUCH AS DIABETES | Merck Patent Gesellschaft Beschrankter Haftung (DE) | 2010-09-30 | — | — | US | disclosed |
| WO-2009049731-A1 | IMIDAZO[1,2-A]PYRIMIDINE DERIVATIVES FOR TREATING DISEASES SUCH AS DIABETES | MERCK PATENT GMBH (DE) | 2009-04-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249151-A1 | IMIDAZO 1, 2-A PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF DISEASES SUCH AS DIABETES | TYMS, CCNT1, INSR | PTPN1 872/4885GABRA1 3159/4885GABRB2 3812/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.