Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.34 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.34 |
| ▸ | CYP4F2 | P78329 | 3/20 | 0.33 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 2/20 | 0.32 |
| ▸ | CNR2 | P34972 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9901198 | 0.91 | PTPN1 (0.37) | PTPN1KDM4EALOX5PTGS2LTB4R | |
| SCHEMBL6283334 | 0.85 | PTPN1 (0.40) | PTPN1ALOX5PTGS2PDCD1CD274 | |
| SCHEMBL10434845 | 0.83 | PTPN1 (0.38) | PTPN1KDM4EALOX5PTGS2PDCD1 | |
| SCHEMBL9900695 | 0.80 | BACE1 (0.34) | PTPN1TLR7 | |
| SCHEMBL3903483 | 0.79 | PDCD1 (0.44) | PTPN1CYP4F2CYP4A11PDCD1CD274 | |
| SCHEMBL8973880 | 0.78 | ALOX5 (0.37) | PTPN1KDM4EALOX5PTGS2DHODH | |
| SCHEMBL2048597 | 0.77 | EGFR (0.41) | PTPN1KDM4EEGFR | |
| SCHEMBL15533377 | 0.77 | PTPN1 (0.34) | PTPN1EGFR | |
| SCHEMBL12855014 | 0.76 | PTPN1 (0.41) | PTPN1KDM4EALOX5PTGS2LTB4R | |
| SCHEMBL30566658 | 0.76 | PTPN1 (0.46) | PTPN1KDM4EPDCD1CD274EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2649066-A1 | HYDANTOIN DERIVATIVES USEFUL AS KV3 INHIBITORS | Autifony Therapeutics Limited (GB) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012076877-A1 | HYDANTOIN DERIVATIVES USEFUL AS KV3 INHIBITORS | AUTIFONY THERAPEUTICS LIMITED (GB) | 2012-06-14 | — | — | WO | disclosed |