Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 5/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | DAO | P14920 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2204294 | 0.73 | FLT3 (0.49) | FLT3MAOBHRH4HRH3KDM4E | |
| SCHEMBL7024844 | 0.71 | FLT3 (0.62) | FLT3MAOBHRH4HRH3KDM4E | |
| SCHEMBL8496203 | 0.69 | HRH4 (0.53) | FLT3MAOBHRH4HRH3KDM4E | |
| SCHEMBL3449404 | 0.69 | HRH4 (0.53) | FLT3MAOBHRH4HRH3KDM4E | |
| SCHEMBL18900665 | 0.69 | FLT3 (0.59) | FLT3MAOBHRH4HRH3KDM4E | |
| SCHEMBL7030607 | 0.68 | FLT3 (0.57) | FLT3MAOBHRH4HRH3KDM4E | |
| SCHEMBL3603280 | 0.68 | KDR (0.59) | FLT3MAOBKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL3603283 | 0.68 | KDR (0.59) | FLT3MAOBKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL370573 | 0.67 | FLT3 (1.00) | FLT3KDM4EMAPTDAOHPGD | |
| SCHEMBL31277139 | 0.67 | FLT3 (0.77) | FLT3HRH4HRH3KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101316838-B | 1,1-dioxo-thiomorpholinyl indolyl methanone derivatives for use as h3 modulators | HOFFMANN LA ROCHE | 2013-01-30 | — | — | CN | disclosed |
| CN-101316838-B | 1,1-dioxo-thiomorpholinyl indolyl methanone derivatives for use as h3 modulators | HOFFMANN LA ROCHE | 2013-01-30 | — | — | CN | disclosed |
| EP-1968967-B1 | 1,1-DIOXO-THIOMORPHOLINYL INDOLYL METHANONE DERIVATIVES FOR USE AS H3 MODULATORS | HOFFMANN LA ROCHE (CH) | 2011-04-27 | — | — | EP | disclosed |
| US-7538101-B2 | 1,1-dioxo-thiomorpholinyl indolyl methanone derivatives | HOFFMANN-LA ROCHE INC. (US) | 2009-05-26 | — | — | US | disclosed |
| US-7538101-B2 | 1,1-dioxo-thiomorpholinyl indolyl methanone derivatives | HOFFMANN-LA ROCHE INC. (US) | 2009-05-26 | — | — | US | disclosed |
| CN-101316838-A | 1,1-dioxo-thiomorpholinyl indolyl methanone derivatives for use as h3 modulators | HOFFMANN LA ROCHE (CH) | 2008-12-03 | — | — | CN | disclosed |
| CN-101316838-A | 1,1-dioxo-thiomorpholinyl indolyl methanone derivatives for use as h3 modulators | HOFFMANN LA ROCHE (CH) | 2008-12-03 | — | — | CN | disclosed |
| EP-1968967-A1 | 1,1-DIOXO-THIOMORPHOLINYL INDOLYL METHANONE DERIVATIVES FOR USE AS H3 MODULATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007062997-A1 | 1,1-DIOXO-THIOMORPHOLINYL INDOLYL METHANONE DERIVATIVES FOR USE AS H3 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-06-07 | — | — | WO | disclosed |
| US-20070123526-A1 | 1,1-Dioxo-thiomorpholinyl indolyl methanone derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2007-05-31 | — | — | US | disclosed |
| US-20070123526-A1 | 1,1-Dioxo-thiomorpholinyl indolyl methanone derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2007-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070123526-A1 | 1,1-Dioxo-thiomorpholinyl indolyl methanone derivatives | MTNR1A, HTR1A, HRH4 | FLT3 3405/4885MAOB 647/4885HRH4 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.