Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 7/20 | 0.36 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.33 |
| ▸ | PDE4A | P27815 | 4/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.32 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.31 |
| ▸ | FABP4 | P15090 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1555420 | 0.85 | PTGER4 (0.37) | SLC22A12PTGER4 | |
| SCHEMBL1554928 | 0.66 | SLC22A12 (0.44) | SLC22A12PTGER4PDE4APDE4BPDE4C | |
| SCHEMBL1554166 | 0.65 | CYSLTR2 (0.42) | SLC22A12PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7402575 | 0.65 | HTR3A (0.38) | PDE4APDE4BPDE4CPDE4D | |
| Hydrochloric Acid SCHEMBL8571276 | 0.65 | SLC22A12 (0.44) | SLC22A12PTGER4PDE4APDE4BPDE4C | |
| SCHEMBL1552977 | 0.64 | CYSLTR2 (0.42) | SLC22A12PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL1553381 | 0.64 | CYSLTR2 (0.42) | SLC22A12PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL1553899 | 0.64 | SLC22A12 (0.54) | SLC22A12PTGER4PDE4APDE4BPDE4C | |
| SCHEMBL1553876 | 0.63 | CYSLTR2 (0.40) | SLC22A12PDE4APDE4BPDE4CPDE4D | |
| Hydrochloric Acid SCHEMBL8602666 | 0.63 | SLC22A12 (0.53) | SLC22A12PTGER4PDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2102199-B1 | ANTIBACTERIAL POLYCYCLIC UREA COMPOUNDS | ASTRAZENECA AB (SE) | 2011-04-27 | — | — | EP | claimed |
| EP-0934307-B1 | SUBSTITUTED AZABICYLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF THE PRODUCTION OF TNF AND CYCLIC AMP PHOSPHODIESTERASE | AVENTIS PHARMA LTD (GB) | 2011-04-27 | — | — | EP | disclosed |
| EP-2223920-A2 | Substituted azabicyclic compounds | Aventis Pharma Limited (GB) | 2010-09-01 | — | — | EP | disclosed |
| US-7329675-B2 | Substituted azabicyclic compounds | AVENTIS PHARMA LIMITED (GB) | 2008-02-12 | — | — | US | disclosed |
| US-20050038069-A1 | Substituted azabicyclic compounds | AVENTIS PHARMA LIMITED (GB) | 2005-02-17 | — | — | US | disclosed |
| US-6800645-B1 | INHIBIT PRODUCTION OR PHYSIOLOGICAL EFFECTS OF TNF, INHIBIT CYCLIC AMP PHOSPHODIESTERASE | AVENTIS PHARMA LIMITED (GB) | 2004-10-05 | — | — | US | disclosed |
| US-20020173527-A1 | Substituted azabicyclic compounds | ASTLES PETER CHARLES (GB) | 2002-11-21 | — | — | US | disclosed |
| US-6303600-B1 | USED IN THERAPY OF DISEASE STATES ASSOCIATED WITH PROTEINS THAT MEDIATE CELLULAR ACTIVITY | RHONE-POULENC RORER LIMITED (GB) | 2001-10-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020173527-A1 | Substituted azabicyclic compounds | CBR1, NOX1, POR | SLC22A12 3459/4885PTGER4 441/4885PDE4A 76/4885 |
| US-20050038069-A1 | Substituted azabicyclic compounds | NR2C2, NR3C1, NR3C2 | SLC22A12 1326/4885PTGER4 1226/4885PDE4A 3861/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.