Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.53 |
| ▸ | CDK2 | P24941 | 3/20 | 0.53 |
| ▸ | JAK2 | O60674 | 4/20 | 0.52 |
| ▸ | JAK3 | P52333 | 1/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.51 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.50 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.50 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.50 |
| ▸ | IKBKB | O14920 | 1/20 | 0.49 |
| ▸ | CHUK | O15111 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15534241 | 0.88 | CLK1 (0.63) | SYKCDK2JAK2PIK3CAPIK3CG | |
| SCHEMBL12274955 | 0.85 | ABL1 (0.56) | SYKCDK2JAK2PIK3CAPIK3CG | |
| SCHEMBL15534009 | 0.85 | MAPT (0.48) | SYKCDK2JAK2JAK3PIK3CA | |
| SCHEMBL15533684 | 0.85 | DYRK1A (0.47) | SYKCDK2JAK2PIK3CAPIK3CG | |
| SCHEMBL15533545 | 0.85 | DYRK1A (0.49) | SYKCDK2JAK2PIK3CAPIK3CG | |
| SCHEMBL4901089 | 0.84 | MEN1 (0.62) | CDK2JAK2JAK3PIK3CAPIK3CG | |
| SCHEMBL4737479 | 0.84 | PLK1 (0.61) | SYKCDK2JAK2JAK3PIK3CA | |
| SCHEMBL14088787 | 0.84 | JAK2 (0.59) | CDK2JAK2JAK3PIK3CAPIK3CG | |
| SCHEMBL4903233 | 0.82 | JAK2 (0.65) | CDK2JAK2PIK3CAPIK3CGPIK3CB | |
| SCHEMBL25337070 | 0.81 | KCNH2 (0.51) | SYKCDK2MEN1KMT2ACLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013175415-A1 | SUBSTITUTED PYRIMIDINE COMPOUNDS AND USES THEREOF | Piramal Enterprises Limited (IN) | 2013-11-28 | — | — | WO | claimed |
| WO-2013175415-A1 | SUBSTITUTED PYRIMIDINE COMPOUNDS AND USES THEREOF | Piramal Enterprises Limited (IN) | 2013-11-28 | — | — | WO | disclosed |