Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | JAK2 | O60674 | 4/20 | 0.48 |
| ▸ | SYK | P43405 | 4/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.48 |
| ▸ | CDK2 | P24941 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15533865 | 0.85 | SYK (0.53) | MAPTJAK2SYKPIK3CAPIK3CG | |
| SCHEMBL15533252 | 0.81 | DKK1 (0.47) | JAK2SYKPIK3CAPIK3CGPIK3CB | |
| SCHEMBL15534241 | 0.80 | CLK1 (0.63) | MAPTJAK2SYKPIK3CAPIK3CG | |
| SCHEMBL15533965 | 0.80 | SYK (0.51) | MAPTJAK2SYKPIK3CAPIK3CG | |
| SCHEMBL15533704 | 0.80 | ABL1 (0.47) | MAPTJAK2PIK3CAPIK3CGKDM4E | |
| SCHEMBL4901089 | 0.79 | MEN1 (0.62) | JAK2PIK3CAPIK3CGPIK3CBCDK2 | |
| SCHEMBL4737479 | 0.79 | PLK1 (0.61) | JAK2SYKPIK3CAPIK3CGPIK3CB | |
| SCHEMBL14088787 | 0.79 | JAK2 (0.59) | JAK2PIK3CAPIK3CGPIK3CBCDK2 | |
| SCHEMBL4903233 | 0.79 | JAK2 (0.65) | JAK2PIK3CAPIK3CGPIK3CBCDK2 | |
| SCHEMBL15533684 | 0.78 | DYRK1A (0.47) | MAPTJAK2SYKPIK3CAPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013175415-A1 | SUBSTITUTED PYRIMIDINE COMPOUNDS AND USES THEREOF | Piramal Enterprises Limited (IN) | 2013-11-28 | — | — | WO | claimed |
| WO-2013175415-A1 | SUBSTITUTED PYRIMIDINE COMPOUNDS AND USES THEREOF | Piramal Enterprises Limited (IN) | 2013-11-28 | — | — | WO | disclosed |