Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.54 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.49 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | LTA4H | P09960 | 1/20 | 0.48 |
| ▸ | PRKCA | P17252 | 1/20 | 0.48 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | BCL2 | P10415 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | ACACB | O00763 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23684597 | 0.87 | SYK (0.51) | SYKADRB2ADRB3SMN1; SMN2ALOX5 | |
| SCHEMBL30771411 | 0.87 | SYK (0.53) | SYKADRB2ADRB1ADRB3HDAC1 | |
| SCHEMBL6431215 | 0.86 | PRKCA (0.60) | SYKADRB2ADRB1ADRB3HDAC1 | |
| SCHEMBL31724393 | 0.85 | SYK (0.54) | SYKADRB2ADRB1ADRB3HDAC1 | |
| SCHEMBL9533724 | 0.85 | SYK (0.51) | SYKADRB2ADRB1ADRB3HDAC1 | |
| SCHEMBL20425275 | 0.85 | SYK (0.53) | SYKADRB2ADRB1ADRB3HDAC1 | |
| SCHEMBL1624911 | 0.85 | NPC1 (0.58) | SYKNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL350453 | 0.85 | NPC1 (0.58) | SYKNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL7739354 | 0.85 | NPC1 (0.58) | SYKNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL7428451 | 0.84 | ADRB2 (0.53) | SYKADRB2ADRB1ADRB3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486030-A1 | MODULATORS OF G PROTEIN-COUPLED RECEPTOR 88 | Bristol-Myers Squibb Company (US) | 2012-08-15 | — | — | EP | disclosed |
| WO-2011044195-A1 | MODULATORS OF G PROTEIN-COUPLED RECEPTOR 88 | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-04-14 | — | — | WO | disclosed |