Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | MMP1 | P03956 | 1/20 | 0.54 |
| ▸ | MMP2 | P08253 | 1/20 | 0.54 |
| ▸ | MMP9 | P14780 | 1/20 | 0.54 |
| ▸ | MMP8 | P22894 | 1/20 | 0.54 |
| ▸ | MMP13 | P45452 | 1/20 | 0.54 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | CXCR5 | P32302 | 1/20 | 0.50 |
| ▸ | APLNR | P35414 | 1/20 | 0.50 |
| ▸ | CCR6 | P51684 | 1/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.49 |
| ▸ | HTR6 | P50406 | 3/20 | 0.47 |
| ▸ | NAMPT | P43490 | 4/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20758153 | 0.89 | CA1 (0.57) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL8863056 | 0.89 | CA1 (0.65) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL30859041 | 0.89 | CA1 (0.65) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL20757768 | 0.88 | CA1 (0.56) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL7697167 | 0.87 | CA1 (0.59) | CA1CA2MMP1MMP2MMP9 | |
| Hydrochloric Acid SCHEMBL11261755 | 0.87 | CA1 (0.62) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL20758349 | 0.85 | CA1 (0.53) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL10919387 | 0.85 | HSD11B1 (0.54) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL15689511 | 0.85 | HTR6 (0.53) | CA1CA2MMP1MMP2MMP9 | |
| SCHEMBL5122472 | 0.83 | HTR2A (0.51) | HSD11B1HTR6MEN1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2854814-A2 | HETEROARYL-KETONE FUSED AZADECALIN GLUCOCORTICOID RECEPTOR MODULATORS | Corcept Therapeutics, Inc. (US) | 2015-04-08 | — | — | EP | disclosed |
| WO-2013177559-A2 | HETEROARYL-KETONE FUSED AZADECALIN GLUCOCORTICOID RECEPTOR MODULATORS | CORCEPT THERAPEUTICS, INC. (US) | 2013-11-28 | — | — | WO | disclosed |