Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | DAO | P14920 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | PRKAB2 | O43741 | 3/20 | 0.34 |
| ▸ | PRKAG1 | P54619 | 3/20 | 0.34 |
| ▸ | PRKAA2 | P54646 | 3/20 | 0.34 |
| ▸ | PRKAA1 | Q13131 | 3/20 | 0.34 |
| ▸ | PRKAG3 | Q9UGI9 | 3/20 | 0.34 |
| ▸ | PRKAG2 | Q9UGJ0 | 3/20 | 0.34 |
| ▸ | PRKAB1 | Q9Y478 | 3/20 | 0.34 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.34 |
| ▸ | HTR1D | P28221 | 1/20 | 0.33 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13738363 | 0.84 | PDE10A (0.34) | — | |
| SCHEMBL27083544 | 0.81 | MTOR (0.35) | KMT2APDE4DDAOMAPK1PRKAB2 | |
| SCHEMBL16216909 | 0.80 | BACE1 (0.34) | CYP2D6 | |
| SCHEMBL855517 | 0.79 | PIK3CA (0.38) | KMT2AKDM5BCYP1A2CYP2D6MAPT | |
| SCHEMBL25344301 | 0.78 | IDH1 (0.32) | CYP1A2CYP2D6MAPT | |
| SCHEMBL16573747 | 0.78 | BACE1 (0.41) | KMT2ACYP2D6MAPT | |
| SCHEMBL28291336 | 0.76 | MAPT (0.56) | KMT2ACYP1A2CYP2D6MAPTMAPK1 | |
| SCHEMBL15602523 | 0.75 | SLC18A3 (0.47) | KMT2ACYP1A2MAPT | |
| SCHEMBL24157002 | 0.75 | DAO (0.35) | KDM5BDAOPRKAB2PRKAG1PRKAA2 | |
| SCHEMBL16220098 | 0.75 | KDM5B (0.40) | KMT2AKDM5BCYP1A2CYP2D6MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2852584-B1 | SUBSTITUTED DIPYRIDYLAMINES AND USES THEREOF | HOFFMANN LA ROCHE (CH) | 2018-02-28 | — | — | EP | disclosed |
| EP-2852584-B1 | SUBSTITUTED DIPYRIDYLAMINES AND USES THEREOF | HOFFMANN LA ROCHE (CH) | 2018-02-28 | — | — | EP | disclosed |
| US-9399636-B2 | Substituted dipyridylamines and uses thereof | GENENTECH, INC. (US) | 2016-07-26 | — | — | US | disclosed |
| US-9399636-B2 | Substituted dipyridylamines and uses thereof | GENENTECH, INC. (US) | 2016-07-26 | — | — | US | disclosed |
| US-9399636-B2 | Substituted dipyridylamines and uses thereof | GENENTECH, INC. (US) | 2016-07-26 | — | — | US | disclosed |
| EP-2852584-A1 | SUBSTITUTED DIPYRIDYLAMINES AND USES THEREOF | F. Hoffmann-La Roche AG (CH) | 2015-04-01 | — | — | EP | disclosed |
| US-20150080367-A1 | SUBSTITUTED DIPYRIDYLAMINES AND USES THEREOF | GENENTECH, INC. (US) | 2015-03-19 | — | — | US | disclosed |
| US-20150080367-A1 | SUBSTITUTED DIPYRIDYLAMINES AND USES THEREOF | GENENTECH, INC. (US) | 2015-03-19 | — | — | US | disclosed |
| US-20150080367-A1 | SUBSTITUTED DIPYRIDYLAMINES AND USES THEREOF | GENENTECH, INC. (US) | 2015-03-19 | — | — | US | disclosed |
| WO-2013174780-A1 | SUBSTITUTED DIPYRIDYLAMINES AND USES THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2013-11-28 | — | — | WO | disclosed |
| WO-2013174780-A1 | SUBSTITUTED DIPYRIDYLAMINES AND USES THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2013-11-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150080367-A1 | SUBSTITUTED DIPYRIDYLAMINES AND USES THEREOF | PDXK, PRMT1, DMPK | KMT2A 711/4885KDM5B 456/4885CYP1A2 3206/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.