Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CASR | P41180 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14046286 | 0.83 | ALDH1A1 (0.61) | KDM4ECYP1A2CYP2C9IDO1TSHR | |
| SCHEMBL6774791 | 0.79 | BRD4 (0.55) | KDM4ECYP1A2CYP2C9IDO1TSHR | |
| SCHEMBL29469169 | 0.78 | ALDH1A1 (0.59) | KDM4ECYP1A2CYP2C9TSHRALDH1A1 | |
| SCHEMBL521100 | 0.78 | ALDH1A1 (0.59) | KDM4ECYP1A2CYP2C9TSHRALDH1A1 | |
| SCHEMBL8374069 | 0.78 | KDM4E (0.46) | KDM4ECYP1A2CYP2C9IDO1TSHR | |
| SCHEMBL2549708 | 0.77 | ALDH1A1 (0.53) | KDM4ETSHRALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL3792891 | 0.77 | ALDH1A1 (0.48) | KDM4ECYP1A2TSHRALDH1A1HPGD | |
| SCHEMBL22587415 | 0.77 | ALDH1A1 (0.48) | KDM4ETSHRALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL13255390 | 0.77 | LMNA (0.51) | KDM4ECYP1A2CYP2C9IDO1TSHR | |
| SCHEMBL3585917 | 0.76 | ALDH1A1 (0.47) | KDM4ETSHRALDH1A1HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2855483-A1 | PYRROLOPYRROLIDINONE COMPOUNDS | Novartis AG (CH) | 2015-04-08 | — | — | EP | disclosed |
| WO-2013175417-A1 | PYRROLOPYRROLIDINONE COMPOUNDS | NOVARTIS AG (CH) | 2013-11-28 | — | — | WO | disclosed |