Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL521100 | 1.00 | ALDH1A1 (0.59) | ALDH1A1HPGDCYP2C19POLBMAPK1 | |
| SCHEMBL28115430 | 0.89 | ALDH1A1 (0.49) | ALDH1A1HPGDCYP2C19POLBMAPK1 | |
| SCHEMBL9945927 | 0.88 | ALDH1A1 (0.55) | ALDH1A1HPGDCYP2C19POLBMAPK1 | |
| SCHEMBL56441 | 0.83 | GAA (0.50) | ALDH1A1HPGDPOLBSMN1; SMN2HSD17B10 | |
| SCHEMBL3149525 | 0.83 | RAB9A (0.45) | ALDH1A1HPGDCYP2C19POLBSMN1; SMN2 | |
| SCHEMBL2549708 | 0.82 | ALDH1A1 (0.53) | ALDH1A1HPGDCYP2C19POLBMAPK1 | |
| SCHEMBL3792891 | 0.82 | ALDH1A1 (0.48) | ALDH1A1HPGDCYP2C19POLBMAPK1 | |
| SCHEMBL6689158 | 0.82 | ALDH1A1 (0.74) | ALDH1A1HPGDCYP2C19POLBMAPK1 | |
| SCHEMBL3585917 | 0.81 | ALDH1A1 (0.47) | ALDH1A1HPGDCYP2C19POLBMAPK1 | |
| SCHEMBL1533800 | 0.81 | NPC1 (0.48) | ALDH1A1HPGDPOLBSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12083121-B2 | Substituted piperazines as KRAS G12C inhibitors | AMGEN INC. (US) | 2024-09-10 | — | — | US | disclosed |
| CN-118401108-A | Lactones for enhancing the activity of antimicrobial agents | 巴斯夫欧洲公司 | 2024-07-26 | — | — | CN | disclosed |
| US-20220340893-A1 | BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES | NUEVOLUTION A/S (DK) | 2022-10-27 | — | — | US | disclosed |
| EP-4045625-A1 | STORAGE-STABLE HYDROLASE CONTAINING LIQUIDS | BASF SE (DE) | 2022-08-24 | — | — | EP | disclosed |
| EP-4034650-A1 | MANNANASE FOR FORMULATIONS HAVING PH 5-12 | BASF SE (DE) | 2022-08-03 | — | — | EP | disclosed |
| EP-4034651-A1 | MANNANASE FOR FORMULATIONS HAVING PH 5-12 | BASF SE (DE) | 2022-08-03 | — | — | EP | disclosed |
| US-20220175782-A1 | KRAS G12C INHIBITORS AND METHODS OF USING THE SAME | AMGEN INC. | 2022-06-09 | — | — | US | disclosed |
| US-11285156-B2 | Substituted piperazines as KRAS G12C inhibitors | AMGEN INC. (US) | 2022-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11285156-B2 | Substituted piperazines as KRAS G12C inhibitors | KRAS, NRAS, HRAS | ALDH1A1 3126/4885HPGD 1474/4885CYP2C19 3954/4885 |
| US-12083121-B2 | Substituted piperazines as KRAS G12C inhibitors | KRAS, NRAS, HRAS | ALDH1A1 3126/4885HPGD 1474/4885CYP2C19 3954/4885 |
| US-20220175782-A1 | KRAS G12C INHIBITORS AND METHODS OF USING THE SAME | KRAS, NRAS, HRAS | ALDH1A1 4307/4885HPGD 2379/4885CYP2C19 4667/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.