Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.35 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.35 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.35 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL602378 | 0.84 | ALDH1A1 (0.52) | ALDH1A1LMNAGAAGRIN2DGRIN3B | |
| SCHEMBL21753438 | 0.78 | GRIN2D (0.56) | LMNAGAAP2RX7GRIN2DGRIN3B | |
| Hydrochloric Acid SCHEMBL31374405 | 0.77 | GRIN2D (0.54) | ALDH1A1LMNAGAAP2RX7GRIN2D | |
| SCHEMBL18788533 | 0.76 | PKM (0.48) | ALDH1A1LMNAGAAGRIN2DGRIN3B | |
| SCHEMBL18788534 | 0.76 | PKM (0.48) | ALDH1A1LMNAGAAGRIN2DGRIN3B | |
| SCHEMBL1044999 | 0.76 | PKM (0.48) | ALDH1A1LMNAGAAGRIN2DGRIN3B | |
| SCHEMBL2574454 | 0.75 | GRIN2D (0.33) | LMNAGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL4752629 | 0.74 | GRIN2D (0.56) | ALDH1A1LMNAGAAGRIN2DGRIN3B | |
| SCHEMBL6058620 | 0.74 | GRIN2D (0.64) | ALDH1A1LMNAGAAGRIN2DGRIN3B | |
| SCHEMBL1771507 | 0.74 | ALDH1A1 (0.45) | ALDH1A1LMNAGAAGRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2855428-A1 | N-SUBSTITUTED BENZAMIDES AND THEIR USE IN THE TREATMENT OF PAIN | Genentech, Inc. (US) | 2015-04-08 | — | — | EP | disclosed |
| WO-2013177224-A1 | N-SUBSTITUTED BENZAMIDES AND THEIR USE IN THE TREATMENT OF PAIN | GENENTECH, INC. (US) | 2013-11-28 | — | — | WO | disclosed |