Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | IDO1 | P14902 | 2/20 | 0.44 |
| ▸ | AGXT | P21549 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9414387 | 0.80 | ALDH1A1 (0.40) | ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL10881311 | 0.78 | CXCR3 (0.41) | ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10881315 | 0.78 | CXCR3 (0.41) | ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10881322 | 0.78 | CXCR3 (0.41) | ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL34413 | 0.78 | IDO1 (0.67) | ALDH1A1SMN1; SMN2TSHRIDO1AGXT | |
| Methoxymethane SCHEMBL28823290 | 0.76 | IDO1 (0.64) | ALDH1A1SMN1; SMN2TSHRIDO1AGXT | |
| Bromide SCHEMBL28558295 | 0.76 | IDO1 (0.64) | ALDH1A1SMN1; SMN2TSHRIDO1AGXT | |
| Hydrochloric Acid SCHEMBL28912134 | 0.76 | IDO1 (0.68) | ALDH1A1SMN1; SMN2TSHRIDO1AGXT | |
| Potassium SCHEMBL1477050 | 0.76 | IDO1 (0.64) | ALDH1A1SMN1; SMN2TSHRIDO1AGXT | |
| SCHEMBL1475481 | 0.76 | IDO1 (0.64) | ALDH1A1SMN1; SMN2TSHRIDO1AGXT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2855428-A1 | N-SUBSTITUTED BENZAMIDES AND THEIR USE IN THE TREATMENT OF PAIN | Genentech, Inc. (US) | 2015-04-08 | — | — | EP | disclosed |
| US-8952169-B2 | N-substituted benzamides and methods of use thereof | XENON PHARMACEUTICALS INC. (CA) | 2015-02-10 | — | — | US | disclosed |
| US-8952169-B2 | N-substituted benzamides and methods of use thereof | XENON PHARMACEUTICALS INC. (CA) | 2015-02-10 | — | — | US | disclosed |
| WO-2013177224-A1 | N-SUBSTITUTED BENZAMIDES AND THEIR USE IN THE TREATMENT OF PAIN | GENENTECH, INC. (US) | 2013-11-28 | — | — | WO | disclosed |