Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 5/20 | 0.54 |
| ▸ | KDM1A | O60341 | 4/20 | 0.41 |
| ▸ | KDM1B | Q8NB78 | 3/20 | 0.41 |
| ▸ | NAAA | Q02083 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | THRA | P10827 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | DRD4 | P21917 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16387298 | 0.75 | SCN9A (0.55) | SCN9AKDM1AKDM1BKCNH2 | |
| SCHEMBL31207397 | 0.74 | FFAR4 (0.40) | SCN9AKDM1AKDM1B | |
| SCHEMBL21779370 | 0.74 | DPP4 (0.45) | SCN9ANAAAHTR1AKDM4EL3MBTL1 | |
| SCHEMBL31207461 | 0.73 | ACACB (0.36) | SCN9AKDM1AKDM1B | |
| SCHEMBL30198976 | 0.73 | CXCR3 (0.49) | SCN9ANAAAKDM4EL3MBTL1DRD4 | |
| SCHEMBL16448706 | 0.72 | SCN9A (0.64) | SCN9ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL27494486 | 0.72 | KDM4E (0.37) | SCN9AKDM4EL3MBTL1ALDH1A1 | |
| SCHEMBL21779364 | 0.71 | DRD4 (0.44) | KDM4EDRD4DRD3SIGMAR1KCNH2 | |
| SCHEMBL18615735 | 0.71 | NAAA (0.59) | SCN9AKDM1AKDM1BNAAAHTR1A | |
| SCHEMBL16448571 | 0.71 | SCN9A (1.00) | SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2855428-A1 | N-SUBSTITUTED BENZAMIDES AND THEIR USE IN THE TREATMENT OF PAIN | Genentech, Inc. (US) | 2015-04-08 | — | — | EP | disclosed |
| US-8952169-B2 | N-substituted benzamides and methods of use thereof | XENON PHARMACEUTICALS INC. (CA) | 2015-02-10 | — | — | US | disclosed |
| US-8952169-B2 | N-substituted benzamides and methods of use thereof | XENON PHARMACEUTICALS INC. (CA) | 2015-02-10 | — | — | US | disclosed |
| WO-2013177224-A1 | N-SUBSTITUTED BENZAMIDES AND THEIR USE IN THE TREATMENT OF PAIN | GENENTECH, INC. (US) | 2013-11-28 | — | — | WO | disclosed |