SCHEMBL15538196

SCHEMBL15538196

CCC(F)(CC)CN1CCC(COc2ccc(-c3ccc(C(=O)O)c(C#N)c3)cc2)CC1

nearest known ligand 0.43

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
SSTR5 P35346 1/20 0.43
KCNH2 Q12809 1/20 0.43
SIGMAR1 Q99720 5/20 0.41
RARA P10276 1/20 0.40
RARB P10826 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15538844 0.91 SSTR5 (0.42) SSTR5KCNH2SIGMAR1
SCHEMBL15539161 0.88 RARA (0.54) SSTR5KCNH2RARARARB
SCHEMBL21042935 0.87 SSTR5 (0.44) SSTR5KCNH2RARARARB
SCHEMBL15538652 0.85 XDH (0.45) SSTR5KCNH2RARARARB
SCHEMBL16768896 0.85 SSTR5 (0.41) SSTR5KCNH2RARARARB
SCHEMBL15538323 0.84 XDH (0.52) SSTR5KCNH2
SCHEMBL15539858 0.83 SSTR5 (0.55) SSTR5KCNH2RARB
SCHEMBL15537787 0.83 SSTR5 (0.41) SSTR5KCNH2SIGMAR1
SCHEMBL15539114 0.82 SSTR5 (0.47) SSTR5KCNH2SIGMAR1
SCHEMBL15538034 0.82 CHRM2 (0.44) SSTR5KCNH2RARARARB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2858986-A1 PIPERIDINE DERIVATIVES FOR GPR119 AGONIST Chong Kun Dang Pharmaceutical Corp. (KR) 2015-04-15 EP disclosed
WO-2013187646-A1 PIPERIDINE DERIVATIVES FOR GPR119 AGONIST CHONG KUN DANG PHARMACEUTICAL CORP. (KR) 2013-12-19 WO disclosed