Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.58 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.46 |
| ▸ | MEN1 | O00255 | 6/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.42 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.41 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.40 |
| ▸ | UBE2N | P61088 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1553869 | 1.00 | MAPT (0.58) | MAPTPTGS2AKR1C3KMT2AMEN1 | |
| SCHEMBL7689781 | 0.82 | PDCD1 (0.64) | MAPTKMT2AMEN1LMNANPSR1 | |
| SCHEMBL7689784 | 0.82 | PDCD1 (0.64) | MAPTKMT2AMEN1LMNANPSR1 | |
| SCHEMBL6934839 | 0.82 | MEN1 (0.57) | MAPTPTGS2AKR1C3KMT2AMEN1 | |
| SCHEMBL6934835 | 0.82 | MEN1 (0.57) | MAPTPTGS2AKR1C3KMT2AMEN1 | |
| SCHEMBL1554470 | 0.80 | AKR1C3 (0.64) | AKR1C3KMT2AMEN1CYP1A2CYP2C9 | |
| SCHEMBL1554468 | 0.80 | AKR1C3 (0.64) | AKR1C3KMT2AMEN1CYP1A2CYP2C9 | |
| SCHEMBL1676321 | 0.78 | MAPT (0.67) | MAPTPTGS2AKR1C3KMT2AMEN1 | |
| SCHEMBL7248148 | 0.77 | MEN1 (0.64) | MAPTPTGS2AKR1C3KMT2AMEN1 | |
| SCHEMBL1695615 | 0.76 | CA12 (0.47) | MAPTPTGS2KMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1439175-B1 | PYRIMIDINE COMPOUND AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2011-04-27 | — | — | EP | disclosed |