Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 3/20 | 0.64 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.59 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | FBP1 | P09467 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1554470 | 1.00 | AKR1C3 (0.64) | AKR1C3AKR1C2AKR1C1KMT2AMEN1 | |
| SCHEMBL1553869 | 0.80 | MAPT (0.58) | AKR1C3AKR1C2KMT2AMEN1ALDH1A1 | |
| SCHEMBL1553872 | 0.80 | MAPT (0.58) | AKR1C3AKR1C2KMT2AMEN1ALDH1A1 | |
| SCHEMBL6934616 | 0.78 | ALDH1A1 (0.67) | AKR1C3AKR1C2AKR1C1KMT2AMEN1 | |
| SCHEMBL6934618 | 0.78 | ALDH1A1 (0.67) | AKR1C3AKR1C2AKR1C1KMT2AMEN1 | |
| SCHEMBL12709017 | 0.77 | PTGS1 (0.65) | AKR1C3AKR1C2KMT2ACYP1A2CYP3A4 | |
| SCHEMBL5698662 | 0.73 | KMT2A (0.55) | AKR1C3AKR1C2AKR1C1KMT2AMEN1 | |
| SCHEMBL1553884 | 0.73 | MAPT (0.48) | ALDH1A1POLBHTTCYP1A2CYP3A4 | |
| SCHEMBL1553882 | 0.73 | MAPT (0.48) | ALDH1A1POLBHTTCYP1A2CYP3A4 | |
| SCHEMBL5698669 | 0.73 | KMT2A (0.55) | AKR1C3AKR1C2AKR1C1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1439175-B1 | PYRIMIDINE COMPOUND AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2011-04-27 | — | — | EP | disclosed |
| EP-2246344-A1 | Pyrimidine compounds and medicinal composition thereof | Eisai R&D Management Co., Ltd. (JP) | 2010-11-03 | — | — | EP | disclosed |
| US-20090030023-A1 | PYRIMIDINE COMPOUNDS AND MEDICINAL COMPOSITION THEREOF | HARADA HITOSHI | 2009-01-29 | — | — | US | disclosed |
| US-7396836-B2 | Pyrimidine compound and medicinal composition thereof | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2008-07-08 | — | — | US | disclosed |
| EP-1439176-B1 | PYRIMIDONE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | EISAI R&D MAN CO LTD (JP) | 2007-03-21 | — | — | EP | disclosed |
| US-7160892-B2 | Pyrimidone compounds and pharmaceutical compositions containing the same | EISAI CO., LTD. (JP) | 2007-01-09 | — | — | US | disclosed |
| US-20050004149-A1 | Pyrimidine compound and medicinal composition thereof | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2005-01-06 | — | — | US | disclosed |
| EP-1439176-A1 | PYRIMIDONE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | Eisai Co., Ltd. (JP) | 2004-07-21 | — | — | EP | disclosed |
| EP-1439175-A1 | PYRIMIDINE COMPOUND AND MEDICINAL COMPOSITION THEREOF | Eisai Co., Ltd. (JP) | 2004-07-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090030023-A1 | PYRIMIDINE COMPOUNDS AND MEDICINAL COMPOSITION THEREOF | CBR3, AHR, HCCS | AKR1C3 76/4885AKR1C2 203/4885AKR1C1 179/4885 |
| US-20050004149-A1 | Pyrimidine compound and medicinal composition thereof | ADORA2B, ADORA2A, ADORA3 | AKR1C3 59/4885AKR1C2 119/4885AKR1C1 134/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.