Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDXK | O00764 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.37 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.36 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.36 |
| ▸ | POLQ | O75417 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | SHBG | P04278 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5743495 | 0.83 | RECQL (0.39) | PDXKALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL13547520 | 0.81 | NOS3 (0.59) | ALDH1A1NOS3NOS1NOS2LMNA | |
| SCHEMBL7996292 | 0.81 | NOS3 (0.39) | ALDH1A1KDM4ENOS3NOS1NOS2 | |
| SCHEMBL29416192 | 0.80 | PDXK (0.45) | PDXKALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL903476 | 0.80 | PDXK (0.45) | PDXKALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL24250694 | 0.79 | NOS3 (0.42) | ALDH1A1KDM4ENOS3NOS1NOS2 | |
| SCHEMBL15538658 | 0.79 | NOS3 (0.38) | ALDH1A1KDM4ENOS3NOS1NOS2 | |
| SCHEMBL992612 | 0.78 | PDXK (0.44) | PDXKALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL29411201 | 0.78 | PDXK (0.44) | PDXKALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL7880211 | 0.78 | UHRF1 (0.46) | PDXKALDH1A1KDM4EHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10472350-B2 | Soluble guanylate cyclase activators and their use | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-11-12 | — | — | US | disclosed |
| US-20180194756-A1 | NOVEL SOLUBLE GUANYLATE CYCLASE ACTIVATORS AND THEIR USE | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-07-12 | — | — | US | disclosed |
| US-9938260-B2 | Soluble guanylate cyclase activators and their use | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2018-04-10 | — | — | US | disclosed |
| US-20170305888-A1 | NOVEL SOLUBLE GUANYLATE CYCLASE ACTIVATORS AND THEIR USE | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2017-10-26 | — | — | US | disclosed |
| EP-3194384-A1 | NOVEL SOLUBLE GUANYLATE CYCLASE ACTIVATORS AND THEIR USE | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2017-07-26 | — | — | EP | disclosed |
| WO-2016042536-A1 | NOVEL SOLUBLE GUANYLATE CYCLASE ACTIVATORS AND THEIR USE | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2016-03-24 | — | — | WO | disclosed |
| US-20150181879-A1 | Substituted pyridine compounds having herbicidal activity | BASF SE (DE) | 2015-07-02 | — | — | US | disclosed |
| US-20150181879-A1 | Substituted pyridine compounds having herbicidal activity | BASF SE (DE) | 2015-07-02 | — | — | US | disclosed |
| US-20150181879-A1 | Substituted pyridine compounds having herbicidal activity | BASF SE (DE) | 2015-07-02 | — | — | US | disclosed |
| EP-2855485-A1 | SUBSTITUTED PYRIDINE COMPOUNDS HAVING HERBICIDAL ACTIVITY | BASF SE (DE) | 2015-04-08 | — | — | EP | disclosed |
| WO-2013178585-A1 | SUBSTITUTED PYRIDINE COMPOUNDS HAVING HERBICIDAL ACTIVITY | BASF SE (DE) | 2013-12-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170305888-A1 | NOVEL SOLUBLE GUANYLATE CYCLASE ACTIVATORS AND THEIR USE | GUCY1A2, GUCY1A1, GUCY1B1 | PDXK 2422/4885ALDH1A1 2631/4885KDM4E 2538/4885 |
| US-20150181879-A1 | Substituted pyridine compounds having herbicidal activity | DDT, PNPO, CYP4X1 | PDXK 12/4885ALDH1A1 189/4885KDM4E 850/4885 |
| US-10472350-B2 | Soluble guanylate cyclase activators and their use | GUCY1A2, GUCY1A1, GUCY1B2 | PDXK 2083/4885ALDH1A1 2139/4885KDM4E 2503/4885 |
| US-20180194756-A1 | NOVEL SOLUBLE GUANYLATE CYCLASE ACTIVATORS AND THEIR USE | GUCY1A2, GUCY1A1, GUCY1B1 | PDXK 2422/4885ALDH1A1 2631/4885KDM4E 2538/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.