Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 10/20 | 0.60 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TNKS | O95271 | 1/20 | 0.40 |
| ▸ | GUSB | P08236 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15537447 | 0.85 | MET (0.64) | METGAA | |
| SCHEMBL15538650 | 0.80 | MET (0.56) | METGAAOPRM1OPRK1TNKS | |
| SCHEMBL23621423 | 0.76 | MET (0.75) | METGAAALDH1A1 | |
| SCHEMBL15539468 | 0.74 | MET (0.56) | METGAAHPGD | |
| SCHEMBL12501011 | 0.70 | GAA (1.00) | METGAAMEN1KMT2A | |
| SCHEMBL17243355 | 0.68 | GAA (0.58) | METGAAMEN1KMT2A | |
| SCHEMBL17243356 | 0.68 | GAA (0.58) | METGAAMEN1KMT2A | |
| SCHEMBL12410795 | 0.66 | GAA (0.64) | METGAANPSR1MEN1KMT2A | |
| SCHEMBL12410758 | 0.66 | GAA (0.64) | METGAAMEN1KMT2A | |
| SCHEMBL16652457 | 0.65 | ALDH1A1 (0.68) | GAAKDM4EALDH1A1MAP2K1HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2875006-B1 | ACID CERAMIDASE INHIBITORS AND THEIR USE AS MEDICAMENTS | FONDAZIONE ST ITALIANO TECNOLOGIA (IT) | 2018-12-26 | — | — | EP | disclosed |
| US-9428465-B2 | Acid ceramidase inhibitors and their use as medicaments | FONDAZIONE ISTITUTO ITALIANO DI TECHNOLOGIA (IT) | 2016-08-30 | — | — | US | disclosed |
| EP-2875006-A1 | ACID CERAMIDASE INHIBITORS AND THEIR USE AS MEDICAMENTS | Fondazione Istituto Italiano Di Tecnologia (IT) | 2015-05-27 | — | — | EP | disclosed |
| US-20150111892-A1 | ACID CERAMIDASE INHIBITORS AND THEIR USE AS MEDICAMENTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2015-04-23 | — | — | US | disclosed |
| WO-2013178576-A1 | ACID CERAMIDASE INHIBITORS AND THEIR USE AS MEDICAMENTS | FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (IT) | 2013-12-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150111892-A1 | ACID CERAMIDASE INHIBITORS AND THEIR USE AS MEDICAMENTS | ASAH1, ASAH2, ACER2 | MET 4321/4885GAA 16/4885OPRM1 4667/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.