SCHEMBL1554443

SCHEMBL1554443

CC(C)(Br)C(=O)c1ccc(Sc2ccc(C(=O)C(C)(C)N3CCOCC3)cc2)cc1

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.72
SMN1; SMN2 Q16637 3/20 0.72
MAPK1 P28482 2/20 0.72
TSHR P16473 1/20 0.72
HRH3 Q9Y5N1 1/20 0.47
LMNA P02545 3/20 0.38
L3MBTL1 Q9Y468 3/20 0.38
HPGD P15428 2/20 0.38
ALOX15 P16050 1/20 0.37
MGLL Q99685 1/20 0.37
HSD17B10 Q99714 1/20 0.37
MLYCD O95822 1/20 0.36
HSP90AA1 P07900 1/20 0.36
HSP90AB1 P08238 1/20 0.36
RAB9A P51151 2/20 0.36
NPC1 O15118 1/20 0.36
KDM4E B2RXH2 1/20 0.35
GSK3B P49841 1/20 0.35
KMT2A Q03164 2/20 0.35
MAPT P10636 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10884364 0.94 ALDH1A1 (0.81) ALDH1A1SMN1; SMN2MAPK1TSHRHRH3
SCHEMBL10889886 0.94 ALDH1A1 (0.81) ALDH1A1SMN1; SMN2MAPK1TSHRHRH3
SCHEMBL18883201 0.89 ALDH1A1 (0.72) ALDH1A1SMN1; SMN2MAPK1TSHRHRH3
SCHEMBL1553588 0.89 ALDH1A1 (0.72) ALDH1A1SMN1; SMN2MAPK1TSHRHRH3
SCHEMBL1554157 0.89 ALDH1A1 (0.72) ALDH1A1SMN1; SMN2MAPK1TSHRHRH3
SCHEMBL9679529 0.89 SMN1; SMN2 (0.72) ALDH1A1SMN1; SMN2MAPK1TSHRHRH3
SCHEMBL8176787 0.88 ALDH1A1 (0.71) ALDH1A1SMN1; SMN2MAPK1TSHRHRH3
SCHEMBL10886640 0.85 ALDH1A1 (0.81) ALDH1A1SMN1; SMN2MAPK1TSHRHRH3
SCHEMBL7100574 0.85 ALDH1A1 (0.67) ALDH1A1SMN1; SMN2MAPK1TSHRHRH3
SCHEMBL18883164 0.85 ALDH1A1 (0.67) ALDH1A1SMN1; SMN2MAPK1TSHRHRH3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1670740-B1 CLEAR PHOTOPOLYMERIZABLE SYSTEMS FOR THE PREPARATION OF HIGH THICKNESS COATINGS LAMBERTI SPA (IT) 2011-04-27 EP disclosed
US-7534880-B2 Clear photopolymerizable systems for the preparation of high thickness coatings LAMBERTI SPA (IT) 2009-05-19 US disclosed
US-20060246228-A1 Clear photopolymerizable systems for the preparation of high thickness coatings LAMBERTI SPA (IT) 2006-11-02 US disclosed
EP-1670740-A2 CLEAR PHOTOPOLYMERIZABLE SYSTEMS FOR THE PREPARATION OF HIGH THICKNESS COATINGS Lamberti Spa (IT) 2006-06-21 EP disclosed
WO-2005014515-A2 CLEAR PHOTOPOLYMERIZABLE SYSTEMS FOR THE PREPARATION OF HIGH THICKNESS COATINGS LAMBERTI SPA (IT) 2005-02-17 WO disclosed
EP-1131286-B1 BIFUNCTIONAL PHOTOINITIATORS SUITABLE FOR PHOTOPOLYMERIZATION AND PHOTOPOLYMERIZABLE SYSTEMS CONTAINING THE SAME LAMBERTI SPA (IT) 2003-09-03 EP disclosed
US-6492514-B1 NEW COMPOUNDS CONTAINING IN THE SAME MOLECULE TWO FUNCTIONAL GROUPS, WHICH CAN GIVE RISE TO RADICALS BY A PHOTOCHEMICAL PROCESS. THE COMPOUNDS ARE SUITABLE AS POLYMERISATION PHOTOINITIATORS IN PHOTOPOLYMERISABLE FORMULATIONS CONTAINING LAMBERTI S.P.A. (IT) 2002-12-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060246228-A1 Clear photopolymerizable systems for the preparation of high thickness coatings CDH1, CLTA, VCL ALDH1A1 4625/4885SMN1; SMN2 4319/4885MAPK1 4176/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.