Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK9 | P50750 | 5/20 | 0.56 |
| ▸ | CDK2 | P24941 | 5/20 | 0.56 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.56 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.56 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.56 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.56 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.56 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.56 |
| ▸ | CDC7 | O00311 | 5/20 | 0.55 |
| ▸ | PIM1 | P11309 | 4/20 | 0.55 |
| ▸ | PRKACA | P17612 | 4/20 | 0.55 |
| ▸ | GSK3B | P49841 | 4/20 | 0.55 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.55 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.55 |
| ▸ | HIPK2 | Q9H2X6 | 3/20 | 0.55 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.55 |
| ▸ | CDK8 | P49336 | 2/20 | 0.55 |
| ▸ | CLK2 | P49760 | 2/20 | 0.55 |
| ▸ | CDK7 | P50613 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29869606 | 1.00 | CDK9 (0.56) | CDK9CDK2CDK5PDPK1CCNT1 | |
| SCHEMBL5618155 | 0.80 | TGFBR1 (0.71) | CDK9CDK2CDK5PDPK1CCNT1 | |
| SCHEMBL25787852 | 0.78 | PRKCI (0.63) | CDK9CDK2CDK5PDPK1CCNT1 | |
| SCHEMBL29364420 | 0.78 | PRKCI (0.63) | CDK9CDK2CDK5PDPK1CCNT1 | |
| SCHEMBL3722012 | 0.77 | CDK9 (0.56) | CDK9CDK2CDK5PDPK1CCNT1 | |
| SCHEMBL8939620 | 0.77 | CDC7 (0.80) | CDK9CDK2CDK5PDPK1CCNT1 | |
| SCHEMBL1050911 | 0.75 | TGFBR1 (0.60) | CDK9CDK2CDK5PDPK1CCNT1 | |
| SCHEMBL29869992 | 0.75 | CDK9 (0.57) | CDK9CDK2CDK5PDPK1CCNT1 | |
| SCHEMBL12676548 | 0.75 | CDK9 (0.57) | CDK9CDK2CDK5PDPK1CCNT1 | |
| SCHEMBL13008012 | 0.75 | CDK9 (0.69) | CDK9CDK2CDK5PDPK1CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9353107-B2 | 3-(pyrazolyl)-1H-pyrrolo[2,3-b]pyridine derivatives as kinase inhibitors | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2016-05-31 | — | — | US | disclosed |
| US-9353107-B2 | 3-(pyrazolyl)-1H-pyrrolo[2,3-b]pyridine derivatives as kinase inhibitors | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2016-05-31 | — | — | US | disclosed |
| US-9353107-B2 | 3-(pyrazolyl)-1H-pyrrolo[2,3-b]pyridine derivatives as kinase inhibitors | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2016-05-31 | — | — | US | disclosed |
| US-20150336949-A1 | 3-(Pyrazolyl)-1H-Pyrrolo[2,3-b]Pyridine Derivatives as Kinase Inhibitors | Um Pharmauji Sdn. Bhd. (MY) | 2015-11-26 | — | — | US | disclosed |
| US-20150336949-A1 | 3-(Pyrazolyl)-1H-Pyrrolo[2,3-b]Pyridine Derivatives as Kinase Inhibitors | Um Pharmauji Sdn. Bhd. (MY) | 2015-11-26 | — | — | US | disclosed |
| US-20150336949-A1 | 3-(Pyrazolyl)-1H-Pyrrolo[2,3-b]Pyridine Derivatives as Kinase Inhibitors | Um Pharmauji Sdn. Bhd. (MY) | 2015-11-26 | — | — | US | disclosed |
| EP-2867233-A1 | 3-(PYRAZOLYL)-1H-PYRROLO[2,3-b]PYRIDINE DERIVATIVES AS KINASE INHIBITORS | Aurigene Discovery Technologies Limited (IN) | 2015-05-06 | — | — | EP | disclosed |
| EP-2867233-A1 | 3-(PYRAZOLYL)-1H-PYRROLO[2,3-b]PYRIDINE DERIVATIVES AS KINASE INHIBITORS | Aurigene Discovery Technologies Limited (IN) | 2015-05-06 | — | — | EP | disclosed |
| EP-2867233-A1 | 3-(PYRAZOLYL)-1H-PYRROLO[2,3-b]PYRIDINE DERIVATIVES AS KINASE INHIBITORS | Aurigene Discovery Technologies Limited (IN) | 2015-05-06 | — | — | EP | disclosed |
| WO-2014006554-A1 | 3-(PYRAZOLYL)-1H-PYRROLO[2,3-b]PYRIDINE DERIVATIVES AS KINASE INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2014-01-09 | — | — | WO | disclosed |
| WO-2014006554-A1 | 3-(PYRAZOLYL)-1H-PYRROLO[2,3-b]PYRIDINE DERIVATIVES AS KINASE INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2014-01-09 | — | — | WO | disclosed |
| WO-2014006554-A1 | 3-(PYRAZOLYL)-1H-PYRROLO[2,3-b]PYRIDINE DERIVATIVES AS KINASE INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2014-01-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150336949-A1 | 3-(Pyrazolyl)-1H-Pyrrolo[2,3-b]Pyridine Derivatives as Kinase Inhibitors | MAP3K3, MAP3K1, MAP3K6 | CDK9 284/4885CDK2 93/4885CDK5 191/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.