Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 3/20 | 0.48 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.48 |
| ▸ | PGR | P06401 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | RORA | P35398 | 1/20 | 0.46 |
| ▸ | RORC | P51449 | 1/20 | 0.46 |
| ▸ | RORB | Q92753 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12963428 | 0.71 | PGR (0.61) | PLK1APOBEC3GPGRKDM4EALDH1A1 | |
| SCHEMBL11500202 | 0.70 | GAA (0.46) | PLK1APOBEC3GKDM4ELMNAALDH1A1 | |
| SCHEMBL22845300 | 0.68 | KDM4C (0.48) | PLK1KDM4EALDH1A1TDP1MAPT | |
| SCHEMBL12963521 | 0.68 | GAA (0.54) | PGRKDM4EPOLBALDH1A1HPGD | |
| SCHEMBL13386557 | 0.68 | ALDH1A1 (0.71) | PGRKDM4EPOLBLMNAALDH1A1 | |
| SCHEMBL6400912 | 0.67 | PGR (0.64) | PLK1APOBEC3GPGRKDM4EPOLB | |
| SCHEMBL8649693 | 0.67 | PLK1 (0.52) | PLK1APOBEC3GPGRKDM4EPOLB | |
| SCHEMBL12963546 | 0.67 | PGR (0.59) | PLK1PGRKDM4EALDH1A1GAA | |
| SCHEMBL30854944 | 0.66 | ALDH1A1 (0.62) | PGRKDM4EPOLBLMNAALDH1A1 | |
| SCHEMBL153959 | 0.66 | ALDH1A1 (0.62) | PGRKDM4EPOLBLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2861597-A1 | SUBSTITUTED PYRAZOLOQUINAZOLINONES AND PYRROLOQUINAZOLINONES AS ALLOSTERIC MODULATORS OF GROUP II METABOTROPIC GLUTAMATE RECEPTORS | Domain Therapeutics (FR) | 2015-04-22 | — | — | EP | disclosed |
| WO-2013174822-A1 | SUBSTITUTED PYRAZOLOQUINAZOLINONES AND PYRROLOQUINAZOLINONES AS ALLOSTERIC MODULATORS OF GROUP II METABOTROPIC GLUTAMATE RECEPTORS | DOMAIN THERAPEUTICS (FR) | 2013-11-28 | — | — | WO | disclosed |