ATP1A2

Sodium/potassium-transporting ATPase subunit · P50993 · ATP1A2 on Sugi Atlas →

17,667 patent compounds predicted against ATP1A2, 10,169 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Metildigoxin (SCHEMBL43349)	0.89	16/20
Digoxin (SCHEMBL20506)	1.00	15/20
Digoxin (SCHEMBL126382)	1.00	15/20
Digoxin (SCHEMBL428012)	1.00	15/20
Digoxin (SCHEMBL597821)	0.94	15/20
Digoxin (SCHEMBL1559560)	0.94	15/20
Digoxin (SCHEMBL1584137)	0.93	15/20
Digoxin (SCHEMBL1461589)	0.58	15/20
SCHEMBL475105	0.51	15/20
SCHEMBL475107	0.51	15/20
Digoxin (SCHEMBL1830809)	0.91	14/20
SCHEMBL1302063	0.85	14/20
SCHEMBL1484406	0.65	14/20
Deslanoside (SCHEMBL125311)	0.80	13/20
Deslanoside (SCHEMBL125312)	0.80	13/20
SCHEMBL1483332	0.74	13/20
SCHEMBL1483335	0.74	13/20
Uzarin (SCHEMBL702463)	0.92	12/20
Digitoxigenin Gentiobioside (SCHEMBL702464)	0.92	12/20
Digitoxigenin Gentiobioside (SCHEMBL1652279)	0.92	12/20

Clinical trials — most relevant to ATP1A2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Long-Term Sulfonylurea Response in ABCC8 Neonatal Diabetes (SuResponsSUR)	PHASE4	UNKNOWN
Digoxin Dosing in Heart Failure: A Simplified Nomogram Versus Standard Care	PHASE4	COMPLETED
Long-Term Sulfonylurea Response in KCNJ11 Neonatal Diabetes	PHASE4	COMPLETED
Renal Transplantation and Inhaled Anesthetic Sevoflurane (SEVOREIN)	PHASE3	COMPLETED
The Possible Efficacy and Safety of Lansoprazole Co-administration With Neoadjuvant Chemotherapy in Women With Breast Cancer	PHASE3	COMPLETED
Prevention of Post-Cardiac Surgery Acute Kidney Injury by Proton Pump Inhibitor	PHASE2	COMPLETED
Post-Cardiac Surgery Acute Kidney Injury Prevention by Administration of Proton Pump Inhibitor (P2 Trial)	PHASE2	RECRUITING
Natural History Study of ATP1A3-related Disease	nan	UNKNOWN
Clinical and Molecular Characteristics of Primary Aldosteronism in Blacks	nan	RECRUITING
Genetic Analysis of Heart Channelopathies in Brazilian Patients and Their Relatives	nan	UNKNOWN
Sodium Transport: Genetics and Hypertension	nan	COMPLETED
Genetic and Environmental Determinants of Hypertension	nan	COMPLETED
Regulation of KATP Channels and Na+/K+ ATPase in Relation to Fatigue Development	nan	COMPLETED
Double Blind Crossover Comparison of Diuretics in the Young	nan	UNKNOWN
Artificial Intelligence for the Prioritization of Genetic Background in Brugada Syndrome	nan	COMPLETED
Calcium Handling and Epicardial Ablation	nan	COMPLETED
The Role of Biomarkers in Inherited Cardiac Conditions	nan	WITHDRAWN
Coproporphyrine Isomers and Methotrexate Elimination	nan	COMPLETED
Evaluation of the Effects of KCNQ1 Mutation on Insulin Tolerance and Obsessive Compulsive Features in Long QT Romano-Ward Syndrome Patients.	nan	UNKNOWN
Evaluation of Exercise Testing and Physical Activity in Children and Adolescents Living With Inherited Arrhythmias	nan	RECRUITING
Identification of Genetic Basis of Atrioventricular Conduction Defects: From Congenital Forms to Degenerative Forms	nan	UNKNOWN
Heart and Skeletal Muscle Problems in Neuroacanthocytosis	nan	COMPLETED
Pediatric Cardiomyopathy Mutation Analysis	nan	RECRUITING
Pharmacogenetics and Cardiovascular Events	nan	COMPLETED
Clinical and Genetic Analysis of Enlarged Vestibular Aqueducts	nan	COMPLETED
Sodium Accumulation Study in Haemodialysis: Brain Study	nan	RECRUITING
Glyceryl-Trinitrate-Induced Headache in Patients With Familial Hemiplegic Migraine Type 1 and 2	nan	COMPLETED
The Genetic Basis of Atrial Fibrillation (AF)	nan	COMPLETED
Biomarkers in the Etiology of Idiopathic Intracranial Hypertension	nan	UNKNOWN
Blood Pressure Control in Juveniles - Longitudinal Study	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a ATP1A2 binder may also engage these)

Protein	Name	Similarity
D2WKD8	—	1.000	D2WKD8 →
P50997	—	1.000	P50997 →
Q9N0Z6	—	1.000	Q9N0Z6 →
P04074	—	1.000	P04074 →
Q08DA1	—	1.000	Q08DA1 →
ATP1A1	Sodium/potassium-transporting ATPase subunit alpha-1	1.000	landscape →
Q5RCD8	—	1.000	Q5RCD8 →
P06686	—	1.000	P06686 →
A2VDL6	—	1.000	A2VDL6 →
P30714	—	1.000	P30714 →
Q92123	—	1.000	Q92123 →
Q5RDR3	—	1.000	Q5RDR3 →
P05024	—	1.000	P05024 →
P25489	—	1.000	P25489 →
Q6PIE5	—	1.000	Q6PIE5 →
P06685	—	1.000	P06685 →
Q8VDN2	—	1.000	Q8VDN2 →
P18907	—	1.000	P18907 →
P09572	—	1.000	P09572 →
P24797	—	1.000	P24797 →
Q92030	—	1.000	Q92030 →
Q9YH26	—	1.000	Q9YH26 →
P05025	—	1.000	P05025 →
P58312	—	1.000	P58312 →
ATP1A3	Sodium/potassium-transporting ATPase subunit	1.000	landscape →
Q6PIC6	—	0.999	Q6PIC6 →
P06687	—	0.999	P06687 →
P24798	—	0.999	P24798 →
P13607	—	0.999	P13607 →
P28774	—	0.997	P28774 →