Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 4/20 | 0.38 |
| ▸ | KIF11 | P52732 | 2/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | AGXT | P21549 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17726213 | 0.81 | ADRA2B (0.45) | ADRA2BTSHRGAAGLAPOLB | |
| SCHEMBL9904799 | 0.81 | TSHR (0.43) | TSHRGAAGLAPOLBMAPK1 | |
| SCHEMBL6447369 | 0.80 | TSHR (0.40) | ADRA2BTSHRGAAGLAPOLB | |
| SCHEMBL1381639 | 0.80 | IDO1 (0.50) | IDO1AGXTALDH1A1KDM4E | |
| SCHEMBL31175766 | 0.79 | ADRA2B (0.50) | ADRA2BTSHRGAAGLAPOLB | |
| SCHEMBL26037690 | 0.79 | ADRA2B (0.50) | ADRA2BTSHRGAAGLAPOLB | |
| SCHEMBL7239671 | 0.77 | TAAR1 (0.54) | ADRA2BMAPK1MAPTTDP1KDM4E | |
| SCHEMBL4332045 | 0.77 | ADRA2B (0.49) | ADRA2BTSHRGAAIDO1MAPK1 | |
| SCHEMBL21089028 | 0.77 | ADRA2B (0.49) | ADRA2BTSHRGAAGLAPOLB | |
| SCHEMBL461891 | 0.77 | HTR2A (0.40) | TSHRPOLBIDO1NR1H2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2854814-A2 | HETEROARYL-KETONE FUSED AZADECALIN GLUCOCORTICOID RECEPTOR MODULATORS | Corcept Therapeutics, Inc. (US) | 2015-04-08 | — | — | EP | disclosed |
| WO-2013177559-A2 | HETEROARYL-KETONE FUSED AZADECALIN GLUCOCORTICOID RECEPTOR MODULATORS | CORCEPT THERAPEUTICS, INC. (US) | 2013-11-28 | — | — | WO | disclosed |