Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NNMT | P40261 | 2/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.36 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP8 | P22894 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28699694 | 0.85 | POLB (0.39) | POLBTDP1HSD17B10NNMTKDM4E | |
| SCHEMBL30034021 | 0.80 | POLB (0.44) | POLBTDP1HSD17B10NNMTPTGS1 | |
| SCHEMBL20565255 | 0.80 | POLB (0.44) | POLBTDP1HSD17B10NNMTPTGS1 | |
| SCHEMBL30486603 | 0.79 | PDE4A (0.38) | POLBTDP1NNMTKDM4EMTNR1A | |
| SCHEMBL21383732 | 0.79 | PDE4A (0.38) | POLBTDP1NNMTKDM4EMTNR1A | |
| SCHEMBL30564474 | 0.77 | SRC (0.41) | POLBTDP1HSD17B10PTGS1PTGDR2 | |
| SCHEMBL21383820 | 0.77 | CYP1A2 (0.37) | POLBTDP1NNMTMTNR1AMTNR1B | |
| SCHEMBL30529295 | 0.77 | CYP1A2 (0.37) | POLBTDP1NNMTMTNR1AMTNR1B | |
| SCHEMBL28045757 | 0.74 | TDP1 (0.66) | POLBTDP1HSD17B10NNMTKDM4E | |
| SCHEMBL3149015 | 0.72 | MTNR1A (0.41) | POLBTDP1PTGS1AKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2855483-A1 | PYRROLOPYRROLIDINONE COMPOUNDS | Novartis AG (CH) | 2015-04-08 | — | — | EP | disclosed |
| WO-2013175417-A1 | PYRROLOPYRROLIDINONE COMPOUNDS | NOVARTIS AG (CH) | 2013-11-28 | — | — | WO | disclosed |