Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | NNMT | P40261 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.39 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.39 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.39 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23971222 | 0.84 | L3MBTL1 (0.50) | TDP1POLBNNMTALDH1A1KDM4E | |
| SCHEMBL838850 | 0.79 | NNMT (0.71) | TDP1POLBNNMTALDH1A1KDM4E | |
| SCHEMBL7540568 | 0.79 | TDP1 (0.68) | TDP1POLBNNMTALDH1A1KDM4E | |
| SCHEMBL29859234 | 0.79 | TDP1 (1.00) | TDP1POLBNNMTALDH1A1KDM4E | |
| SCHEMBL198490 | 0.79 | TDP1 (1.00) | TDP1POLBNNMTALDH1A1KDM4E | |
| SCHEMBL7901086 | 0.79 | TDP1 (0.68) | TDP1POLBNNMTALDH1A1KDM4E | |
| SCHEMBL29774201 | 0.79 | TDP1 (0.68) | TDP1POLBNNMTALDH1A1KDM4E | |
| SCHEMBL28297760 | 0.79 | TDP1 (0.62) | TDP1POLBNNMTALDH1A1KDM4E | |
| SCHEMBL2964431 | 0.78 | CYP1A2 (0.44) | TDP1POLBALDH1A1KDM4ESORT1 | |
| SCHEMBL29587695 | 0.78 | CYP1A2 (0.44) | TDP1POLBALDH1A1KDM4ESORT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110520423-A | AMINOTRIAZOLOPYRIDINES AS KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO | 2019-11-29 | — | — | CN | disclosed |
| CN-109476636-A | Compounds that modulate FXR (NR1H4) | 吉利德科学公司 | 2019-03-15 | — | — | CN | disclosed |
| CN-108299400-A | Substituted pyridine as PDE4 inhibitor and substituted pyrazine compound | 达特神经科学(开曼)有限公司 | 2018-07-20 | — | — | CN | disclosed |
| CN-105143207-B | Substituted pyridine and substituted pyrazine compounds as PDE4 inhibitors | 达特神经科学(开曼)有限公司 | 2018-04-24 | — | — | CN | disclosed |
| CN-106687445-A | Pyrazolyl-substituted pyridone compounds as serine protease inhibitors | 维颂公司 | 2017-05-17 | — | — | CN | disclosed |
| CN-105143207-A | Substituted pyridine and substituted pyrazine compounds as PDE4 inhibitors | DART NEUROSCIENCE LLC | 2015-12-09 | — | — | CN | disclosed |