Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 4/20 | 0.41 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.40 |
| ▸ | TPSD1 | Q9BZJ3 | 2/20 | 0.40 |
| ▸ | TPSG1 | Q9NRR2 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 3/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7439259 | 0.79 | L3MBTL1 (0.43) | SYKMAPTBACE1L3MBTL1CTSK | |
| SCHEMBL9766146 | 0.79 | CCR6 (0.52) | SYKMAPTL3MBTL1HTTTPSAB1 | |
| SCHEMBL734565 | 0.78 | SYK (0.53) | SYKMAPTL3MBTL1CTSKCTSS | |
| SCHEMBL13664816 | 0.78 | MAPT (0.48) | SYKMAPTBACE1HTTTPSAB1 | |
| SCHEMBL4896495 | 0.77 | SYK (0.48) | SYKMAPTBACE1L3MBTL1CTSK | |
| SCHEMBL1554884 | 0.77 | SYK (0.48) | SYKMAPTBACE1L3MBTL1CTSK | |
| SCHEMBL6840615 | 0.77 | SYK (0.56) | SYKMAPTHTTCTSKSMN1; SMN2 | |
| SCHEMBL15784783 | 0.77 | SYK (0.57) | SYKMAPTHTTCTSKSMN1; SMN2 | |
| SCHEMBL13665312 | 0.77 | MAPT (0.48) | SYKMAPTL3MBTL1HTTTPSAB1 | |
| SCHEMBL30306840 | 0.77 | SIRT2 (0.50) | SYKMAPTTPSAB1TPSD1TPSG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2491022-A1 | DIAZEPAM DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS | F. Hoffmann-La Roche AG (CH) | 2012-08-29 | — | — | EP | disclosed |
| WO-2011048032-A1 | DIAZEPAM DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-04-28 | — | — | WO | disclosed |