Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | F10 | P00742 | 4/20 | 0.34 |
| ▸ | F2 | P00734 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MITF | O75030 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20475355 | 0.90 | MAPT (0.39) | MAPTLMNAKDM4EF10F2 | |
| SCHEMBL20475329 | 0.88 | MAPT (0.41) | MAPTLMNAKDM4EF10F2 | |
| SCHEMBL20475388 | 0.87 | KDM4E (0.44) | MAPTLMNAKDM4EF10F2 | |
| SCHEMBL20475336 | 0.84 | KDM4E (0.41) | MAPTLMNAKDM4EF10F2 | |
| SCHEMBL1269176 | 0.83 | MAPT (0.46) | MAPTLMNAKDM4EF10F2 | |
| SCHEMBL20475321 | 0.83 | MAPT (0.37) | MAPTLMNAKDM4EF10F2 | |
| SCHEMBL1269119 | 0.81 | F10 (0.43) | MAPTLMNAKDM4EF10F2 | |
| SCHEMBL9294262 | 0.80 | F2 (0.50) | MAPTLMNAKDM4EF10F2 | |
| SCHEMBL6556296 | 0.79 | ALDH1A1 (0.44) | MAPTLMNAKDM4EALDH1A1CYP2C19 | |
| SCHEMBL1269175 | 0.78 | MAPT (0.39) | MAPTLMNAKDM4EF10F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014015675-A1 | NOVEL HETEROARYL AND HETEROCYCLE COMPOUNDS, COMPOSITIONS AND METHODS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2014-01-30 | — | — | WO | disclosed |
| WO-2014012563-A1 | COMPOUNDS FOR ENHANCING THE COGNITIVE FUNCTION | UCB PHARMA, S.A. (BE) | 2014-01-23 | — | — | WO | disclosed |