Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | VCP | P55072 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TNF | P01375 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4809773 | 0.81 | ALDH1A1 (0.50) | ALDH1A1CYP2C19LMNAMAPTKDM4E | |
| SCHEMBL20475329 | 0.80 | MAPT (0.41) | ALDH1A1CYP2C19LMNAMAPTKDM4E | |
| SCHEMBL1269160 | 0.79 | ALOX15 (0.46) | ALDH1A1CYP2C19LMNAMAPTKDM4E | |
| SCHEMBL15548874 | 0.79 | MAPT (0.40) | ALDH1A1CYP2C19LMNAMAPTKDM4E | |
| SCHEMBL1269141 | 0.77 | L3MBTL1 (0.45) | ALDH1A1LMNAMAPTKDM4EMEN1 | |
| SCHEMBL9294262 | 0.77 | F2 (0.50) | ALDH1A1LMNAMAPTKDM4EMEN1 | |
| SCHEMBL20475355 | 0.77 | MAPT (0.39) | ALDH1A1CYP2C19LMNAMAPTKDM4E | |
| SCHEMBL1269548 | 0.75 | F10 (0.44) | ALDH1A1LMNAMAPTKDM4EKMT2A | |
| SCHEMBL20475321 | 0.75 | MAPT (0.37) | ALDH1A1CYP2C19LMNAMAPTKDM4E | |
| SCHEMBL29960595 | 0.75 | ALDH1A1 (0.38) | ALDH1A1CYP2C19LMNAMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958285-B1 | TRICYCLIC BENZO[e]ISOINDOLES AND BENZO[h]ISOQUINOLINES | HOFFMANN LA ROCHE (CH) | 2004-01-07 | — | — | EP | disclosed |
| US-6310208-B1 | Serotonin receptor binding benzo[e]isoindoles and benzo[h]isoquinolines | HOFFMANN-LA ROCHE INC. | 2001-10-30 | — | — | US | disclosed |
| EP-0958285-A1 | TRICYCLIC BENZO[e]ISOINDOLES AND BENZO[h]ISOQUINOLINES | F.HOFFMANN-LA ROCHE AG (CH) | 1999-11-24 | — | — | EP | disclosed |
| WO-1998030546-A1 | TRICYCLIC BENZO[e]ISOINDOLES AND BENZO[h]ISOQUINOLINES | F. HOFFMANN-LA ROCHE AG (CH) | 1998-07-16 | — | — | WO | disclosed |