Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.68 |
| ▸ | MEN1 | O00255 | 8/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.67 |
| ▸ | LMNA | P02545 | 3/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.66 |
| ▸ | FPR2 | P25090 | 1/20 | 0.58 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17535986 | 0.88 | LMNA (0.67) | KMT2AMEN1ALDH1A1LMNAMAPK1 | |
| SCHEMBL8878617 | 0.85 | KMT2A (0.65) | POLBKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL1003394 | 0.84 | MEN1 (0.50) | POLBKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL3984421 | 0.83 | KMT2A (0.46) | POLBKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL16660444 | 0.81 | POLB (0.62) | POLBKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL27616803 | 0.81 | ALDH1A1 (0.51) | POLBKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL5317276 | 0.80 | ALDH1A1 (0.60) | POLBKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL8670380 | 0.78 | LMNA (0.63) | POLBKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL4864670 | 0.77 | L3MBTL1 (0.77) | POLBKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL16056413 | 0.77 | LMNA (0.61) | KMT2AMEN1ALDH1A1LMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2855449-A1 | SULFONYL PIPERIDINE DERIVATIVES AND THEIR USE FOR TREATING PROKINETICIN MEDIATED DISEASES | Takeda Pharmaceutical Company Limited (JP) | 2015-04-08 | — | — | EP | disclosed |
| WO-2014013076-A1 | HEXAHYDROPYRROLOTHIAZINE COMPOUNDS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2014-01-23 | — | — | WO | disclosed |
| WO-2013179024-A1 | SULFONYL PIPERIDINE DERIVATIVES AND THEIR USE FOR TREATING PROKINETICIN MEDIATED DISEASES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-12-05 | — | — | WO | disclosed |