SCHEMBL15549178

SCHEMBL15549178

O=C1CC(c2ccc(F)cc2F)CN1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MTNR1A P48039 2/20 0.50
FPR1 P21462 1/20 0.46
FPR2 P25090 1/20 0.46
TP53 P04637 1/20 0.41
CHRNB2 P17787 2/20 0.41
CHRNB4 P30926 2/20 0.41
CHRNA3 P32297 2/20 0.41
CHRNA4 P43681 2/20 0.41
PDE4A P27815 3/20 0.41
ALDH1A1 P00352 1/20 0.41
CYP1A2 P05177 1/20 0.41
CYP2C19 P33261 1/20 0.41
PDE4B Q07343 1/20 0.41
PDE4C Q08493 1/20 0.41
PDE4D Q08499 1/20 0.41
TSHR P16473 1/20 0.41
CHRNA7 P36544 1/20 0.39
GRM2 Q14416 1/20 0.38
HCAR2 Q8TDS4 1/20 0.38
IDO1 P14902 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18590494 0.84 MTNR1A (0.48) MTNR1ATP53CHRNB2CHRNA4PDE4A
SCHEMBL20001239 0.84 OPRL1 (0.46) FPR1FPR2TP53GRM2HCAR2
SCHEMBL20177600 0.84 MTNR1A (0.48) MTNR1AFPR1FPR2PDE4AALDH1A1
SCHEMBL19988434 0.84 OPRL1 (0.46) FPR1FPR2TP53GRM2HCAR2
SCHEMBL20177704 0.84 MTNR1A (0.48) MTNR1AFPR1FPR2CHRNB2CHRNA4
SCHEMBL29869025 0.81 MTNR1A (0.46) MTNR1ACHRNB2CHRNB4CHRNA3CHRNA4
SCHEMBL18117787 0.80 MTNR1A (0.64) MTNR1AFPR1FPR2PDE4AALDH1A1
SCHEMBL19559399 0.80 MTNR1A (0.64) MTNR1AFPR1FPR2PDE4AALDH1A1
SCHEMBL19996144 0.80 HCAR2 (0.43) MTNR1AFPR1FPR2PDE4AALDH1A1
SCHEMBL29868551 0.80 HCAR2 (0.43) MTNR1AFPR1FPR2PDE4AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2014012563-A1 COMPOUNDS FOR ENHANCING THE COGNITIVE FUNCTION UCB PHARMA, S.A. (BE) 2014-01-23 WO disclosed