Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.69 |
| ▸ | MAPT | P10636 | 1/20 | 0.69 |
| ▸ | HPGD | P15428 | 1/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.69 |
| ▸ | PPARG | P37231 | 5/20 | 0.46 |
| ▸ | PRNP | P04156 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.46 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.46 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.45 |
| ▸ | CHUK | O15111 | 1/20 | 0.44 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31324159 | 0.92 | KDM4E (0.81) | KDM4EALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL31324164 | 0.82 | MEN1 (0.69) | KDM4EALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL1648901 | 0.81 | KDM4E (0.74) | KDM4EALDH1A1MEN1KMT2AMAPT | |
| Methane SCHEMBL506242 | 0.81 | MEN1 (0.67) | KDM4EALDH1A1MEN1KMT2AMAPT | |
| Carbazole SCHEMBL30528387 | 0.80 | ALDH1A1 (0.56) | KDM4EALDH1A1MEN1KMT2AMAPT | |
| Methane SCHEMBL8206725 | 0.80 | KDM4E (0.72) | KDM4EALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL31324193 | 0.79 | MEN1 (0.73) | KDM4EALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL24440010 | 0.79 | KDM4E (0.68) | KDM4EALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL31324185 | 0.78 | KDM4E (0.83) | KDM4EALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL18938363 | 0.78 | KDM4E (0.83) | KDM4EALDH1A1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2852572-A1 | CARBOLINE AND CARBAZOLE BASED IMAGING AGENTS FOR DETECTING NEUROLOGICAL DYSFUNCTION | Eli Lilly and Company (US) | 2015-04-01 | — | — | EP | disclosed |
| WO-2013176698-A1 | CARBOLINE AND CARBAZOLE BASED IMAGING AGENTS FOR DETECTING NEUROLOGICAL DYSFUNCTION | ELI LILLY AND COMPANY (US) | 2013-11-28 | — | — | WO | disclosed |