Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP26A1 | O43174 | 8/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.48 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.48 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.48 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.43 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15798647 | 0.78 | CYP26A1 (0.48) | CYP26A1CYP3A4ALDH1A1HPGDHSD17B10 | |
| SCHEMBL15505827 | 0.77 | ALDH1A1 (0.66) | CYP26A1CYP3A4ALDH1A1HPGDHSD17B10 | |
| SCHEMBL29706072 | 0.77 | ALDH1A1 (0.66) | CYP26A1CYP3A4ALDH1A1HPGDHSD17B10 | |
| SCHEMBL4284727 | 0.77 | CYP26A1 (0.64) | CYP26A1CYP3A4ALDH1A1HPGDHSD17B10 | |
| SCHEMBL11802411 | 0.74 | ALDH1A1 (0.67) | CYP26A1CYP3A4ALDH1A1HPGDHSD17B10 | |
| SCHEMBL29199052 | 0.74 | SIRT2 (0.68) | CYP3A4ALDH1A1HPGDHSD17B10SIRT2 | |
| SCHEMBL9513153 | 0.73 | ALDH1A1 (0.91) | CYP26A1CYP3A4ALDH1A1HPGDHSD17B10 | |
| SCHEMBL29352988 | 0.73 | ALDH1A1 (0.91) | CYP26A1CYP3A4ALDH1A1HPGDHSD17B10 | |
| SCHEMBL39488 | 0.73 | ALDH1A1 (0.91) | CYP26A1CYP3A4ALDH1A1HPGDHSD17B10 | |
| SCHEMBL22146182 | 0.72 | ALDH1A1 (0.58) | CYP26A1CYP3A4ALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160038490-A1 | COMPOSITIONS AND METHODS FOR TREATING DYSPROLIFERATIVE DISEASES | ANGION BIOMEDICA CORP. (US) | 2016-02-11 | — | — | US | claimed |
| WO-2014093960-A1 | COMPOSITIONS AND METHODS FOR TREATING DISEASE | ANGION BIOMEDICA CORP. (US) | 2014-06-19 | — | — | WO | claimed |
| WO-2014015137-A2 | COMPOSITIONS AND METHODS FOR TREATING DYSPROLIFERATIVE DISEASES | ANGION BIOMEDICA CORP. (US) | 2014-01-23 | — | — | WO | claimed |
| US-20160038490-A1 | COMPOSITIONS AND METHODS FOR TREATING DYSPROLIFERATIVE DISEASES | ANGION BIOMEDICA CORP. (US) | 2016-02-11 | — | — | US | disclosed |
| US-20150164907-A1 | COMPOSITIONS AND METHODS FOR TREATING DISEASE | ANGION BIOMEDICA CORP. (US) | 2015-06-18 | — | — | US | disclosed |
| WO-2014093960-A1 | COMPOSITIONS AND METHODS FOR TREATING DISEASE | ANGION BIOMEDICA CORP. (US) | 2014-06-19 | — | — | WO | disclosed |
| WO-2014015137-A2 | COMPOSITIONS AND METHODS FOR TREATING DYSPROLIFERATIVE DISEASES | ANGION BIOMEDICA CORP. (US) | 2014-01-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160038490-A1 | COMPOSITIONS AND METHODS FOR TREATING DYSPROLIFERATIVE DISEASES | DUSP6, CYP26B1, CYP26A1 | CYP26A1 3/4885CYP3A4 458/4885ALDH1A1 664/4885 |
| US-20150164907-A1 | COMPOSITIONS AND METHODS FOR TREATING DISEASE | CDK6, DUSP6, CYP26B1 | CYP26A1 11/4885CYP3A4 1535/4885ALDH1A1 927/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.