Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.79 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.79 |
| ▸ | GAA | P10253 | 3/20 | 0.79 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.79 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.79 |
| ▸ | APEX1 | P27695 | 3/20 | 0.79 |
| ▸ | RECQL | P46063 | 3/20 | 0.79 |
| ▸ | BLM | P54132 | 3/20 | 0.79 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.79 |
| ▸ | POLB | P06746 | 2/20 | 0.79 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | TOP1 | P11387 | 3/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12171193 | 0.90 | MAPT (0.68) | MAPTALDH1A1KMT2AGAAL3MBTL1 | |
| SCHEMBL17069803 | 0.89 | MAPT (0.63) | MAPTALDH1A1KMT2AGAAL3MBTL1 | |
| SCHEMBL12171250 | 0.88 | MAPT (1.00) | MAPTALDH1A1KMT2AGAAL3MBTL1 | |
| SCHEMBL15887547 | 0.84 | MAPT (0.63) | MAPTALDH1A1KMT2AGAAL3MBTL1 | |
| SCHEMBL12171206 | 0.82 | MAPT (0.87) | MAPTALDH1A1KMT2AGAAL3MBTL1 | |
| SCHEMBL14370739 | 0.80 | MAPT (0.79) | MAPTALDH1A1KMT2AGAAL3MBTL1 | |
| SCHEMBL15555870 | 0.78 | MAPT (0.59) | MAPTALDH1A1KMT2AGAAL3MBTL1 | |
| SCHEMBL14370772 | 0.78 | MAPT (0.63) | MAPTALDH1A1KMT2AGAAL3MBTL1 | |
| SCHEMBL17069804 | 0.77 | MAPT (0.79) | MAPTALDH1A1KMT2AGAAL3MBTL1 | |
| Triacetoxyanthrene SCHEMBL9119527 | 0.77 | ALDH1A1 (0.65) | MAPTALDH1A1KMT2AGAAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9517993-B2 | Antagonists of the toll-like receptor 1/2 complex | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2016-12-13 | — | — | US | disclosed |
| US-9517993-B2 | Antagonists of the toll-like receptor 1/2 complex | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2016-12-13 | — | — | US | disclosed |
| US-9517993-B2 | Antagonists of the toll-like receptor 1/2 complex | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2016-12-13 | — | — | US | disclosed |
| US-20150251987-A1 | ANTAGONISTS OF THE TOLL-LIKE RECEPTOR 1/2 COMPLEX | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-09-10 | — | — | US | disclosed |
| US-20150251987-A1 | ANTAGONISTS OF THE TOLL-LIKE RECEPTOR 1/2 COMPLEX | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-09-10 | — | — | US | disclosed |
| US-20150251987-A1 | ANTAGONISTS OF THE TOLL-LIKE RECEPTOR 1/2 COMPLEX | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-09-10 | — | — | US | disclosed |
| EP-2879669-A1 | ANTAGONISTS OF THE TOLL-LIKE RECEPTOR 1/2 COMPLEX | The Regents of The University of Colorado, A Body Corporate (US) | 2015-06-10 | — | — | EP | disclosed |
| WO-2014022287-A1 | ANTAGONISTS OF THE TOLL-LIKE RECEPTOR 1/2 COMPLEX | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2014-02-06 | — | — | WO | disclosed |
| WO-2014022287-A1 | ANTAGONISTS OF THE TOLL-LIKE RECEPTOR 1/2 COMPLEX | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2014-02-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150251987-A1 | ANTAGONISTS OF THE TOLL-LIKE RECEPTOR 1/2 COMPLEX | TLR2, TLR1, TLR3 | MAPT 2900/4885ALDH1A1 4195/4885KMT2A 2587/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.