Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.44 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.44 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.44 |
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
| ▸ | ADK | P55263 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 6/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | CASP6 | P55212 | 1/20 | 0.32 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15554822 | 0.72 | KDM4E (0.43) | ALDH1A1KMT2AADRA1AKDM4E | |
| SCHEMBL16819647 | 0.72 | AURKA (0.31) | — | |
| SCHEMBL9287236 | 0.71 | NISCH (0.64) | CSNK1A1TYRO3DYRK1BNISCHMTOR | |
| SCHEMBL15559746 | 0.70 | — | — | |
| SCHEMBL768219 | 0.70 | NISCH (0.41) | CSNK1A1TYRO3DYRK1BNISCHMTOR | |
| SCHEMBL14886257 | 0.69 | NISCH (0.61) | CSNK1A1TYRO3DYRK1BNISCHMTOR | |
| SCHEMBL28007032 | 0.69 | CSNK1A1 (0.47) | CSNK1A1TYRO3DYRK1BNISCHMTOR | |
| SCHEMBL16819654 | 0.69 | ADRA1A (0.41) | ADRA2AADRA1AADRA1DADRA1B | |
| SCHEMBL15555150 | 0.69 | PDPK1 (0.43) | MTORALDH1A1MEN1KMT2AADRA2A | |
| SCHEMBL15560455 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2864290-B1 | 3-O-HETEROARYL-INGENOL | LEO LABORATORIES LTD (IE) | 2017-06-14 | — | — | EP | disclosed |
| US-9422309-B2 | 3-O-heteroaryl-ingenol | LEO LABORATORIES LIMITED (IE) | 2016-08-23 | — | — | US | disclosed |
| US-20150175622-A1 | 3-O-HETEROARYL-INGENOL | LEO LABORATORIES LIMITED (IE) | 2015-06-25 | — | — | US | disclosed |
| EP-2864290-A2 | 3-O-HETEROARYL-INGENOL | Leo Laboratories Limited (IE) | 2015-04-29 | — | — | EP | disclosed |
| WO-2014001215-A2 | 3-O-HETEROARYL-INGENOL | LEO LABORATORIES LIMITED (IE) | 2014-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150175622-A1 | 3-O-HETEROARYL-INGENOL | VDR, RXRA, PPARG | CSNK1A1 1415/4885TYRO3 3436/4885DYRK1B 1392/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.