Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NSD2 | O96028 | 2/20 | 0.51 |
| ▸ | PTGES2 | Q9H7Z7 | 5/20 | 0.51 |
| ▸ | CCR4 | P51679 | 7/20 | 0.48 |
| ▸ | PGR | P06401 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.46 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3583413 | 0.85 | NSD2 (0.50) | NSD2PGRMAPTKDM4EMEN1 | |
| SCHEMBL8908300 | 0.82 | NSD2 (0.49) | NSD2PTGES2MAPTKDM4EMEN1 | |
| SCHEMBL14676718 | 0.82 | PGR (0.46) | PTGES2CCR4PGRMEN1KMT2A | |
| SCHEMBL2372746 | 0.81 | PTGES2 (0.54) | PTGES2CCR4PGRMCOLN3SLC40A1 | |
| SCHEMBL12932761 | 0.81 | LMNA (0.50) | NSD2CCR4MAPTKDM4EMEN1 | |
| SCHEMBL27621339 | 0.78 | TSHR (0.47) | NSD2MAPTKDM4EMEN1NPC1 | |
| SCHEMBL2803354 | 0.78 | NSD2 (0.58) | NSD2MAPTKDM4EMEN1NPC1 | |
| SCHEMBL1767644 | 0.77 | PTGES2 (0.54) | PTGES2CCR4PGRMCOLN3SLC40A1 | |
| SCHEMBL6255940 | 0.77 | PTGES2 (0.58) | PTGES2CCR4PGRMCOLN3SLC40A1 | |
| SCHEMBL2372744 | 0.77 | PTGES2 (0.54) | PTGES2CCR4PGRMCOLN3SLC40A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3212641-A1 | THIAZOLES AS MODULATORS OF RORyt | Janssen Pharmaceutica NV (BE) | 2017-09-06 | — | — | EP | disclosed |
| WO-2016069976-A1 | THIAZOLES AS MODULATORS OF RORyt | JANSSEN PHARMACEUTICA NV (BE) | 2016-05-06 | — | — | WO | disclosed |
| EP-2855440-A1 | CARBOXAMIDE OR SULFONAMIDE SUBSTITUTED THIAZOLES AND RELATED DERIVATIVES AS MODULATORS FOR THE ORPHAN NUCLEAR RECEPTOR ROR[GAMMA] | Phenex Pharmaceuticals AG (DE) | 2015-04-08 | — | — | EP | disclosed |
| WO-2013178362-A1 | CARBOXAMIDE OR SULFONAMIDE SUBSTITUTED THIAZOLES AND RELATED DERIVATIVES AS MODULATORS FOR THE ORPHAN NUCLEAR RECEPTOR ROR[GAMMA] | PHENEX PHARMACEUTICALS AG (DE) | 2013-12-05 | — | — | WO | disclosed |