Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 5/20 | 0.35 |
| ▸ | FLT3 | P36888 | 5/20 | 0.35 |
| ▸ | KIT | P10721 | 4/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 2/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | PLK4 | O00444 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15560570 | 0.81 | ESR1 (0.48) | ESR1ESR2 | |
| SCHEMBL9960658 | 0.74 | KDR (0.36) | KDRFLT3KITPLK4ROCK2 | |
| SCHEMBL15553918 | 0.73 | TNKS2 (0.39) | NPC1 | |
| SCHEMBL15559971 | 0.72 | ESR1 (0.38) | SMN1; SMN2ESR1ESR2 | |
| SCHEMBL15560139 | 0.72 | ESR1 (0.43) | ESR1ESR2 | |
| SCHEMBL16819668 | 0.69 | ESR1 (0.40) | NPC1RAB9ATP53SMN1; SMN2ESR1 | |
| SCHEMBL16819657 | 0.69 | ACHE (0.37) | NPC1RAB9ATP53SMN1; SMN2ESR1 | |
| SCHEMBL15555685 | 0.67 | EPHX2 (0.37) | SMN1; SMN2 | |
| SCHEMBL617995 | 0.65 | TP53 (0.41) | NPC1RAB9AKDRFLT3KIT | |
| SCHEMBL16819678 | 0.64 | MDM2 (0.31) | NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2864290-B1 | 3-O-HETEROARYL-INGENOL | LEO LABORATORIES LTD (IE) | 2017-06-14 | — | — | EP | claimed |
| US-9422309-B2 | 3-O-heteroaryl-ingenol | LEO LABORATORIES LIMITED (IE) | 2016-08-23 | — | — | US | claimed |
| US-20150175622-A1 | 3-O-HETEROARYL-INGENOL | LEO LABORATORIES LIMITED (IE) | 2015-06-25 | — | — | US | claimed |
| EP-2864290-A2 | 3-O-HETEROARYL-INGENOL | Leo Laboratories Limited (IE) | 2015-04-29 | — | — | EP | claimed |
| WO-2014001215-A2 | 3-O-HETEROARYL-INGENOL | LEO LABORATORIES LIMITED (IE) | 2014-01-03 | — | — | WO | claimed |
| EP-2864290-B1 | 3-O-HETEROARYL-INGENOL | LEO LABORATORIES LTD (IE) | 2017-06-14 | — | — | EP | disclosed |
| US-9422309-B2 | 3-O-heteroaryl-ingenol | LEO LABORATORIES LIMITED (IE) | 2016-08-23 | — | — | US | disclosed |
| US-20150175622-A1 | 3-O-HETEROARYL-INGENOL | LEO LABORATORIES LIMITED (IE) | 2015-06-25 | — | — | US | disclosed |
| EP-2864290-A2 | 3-O-HETEROARYL-INGENOL | Leo Laboratories Limited (IE) | 2015-04-29 | — | — | EP | disclosed |
| WO-2014001215-A2 | 3-O-HETEROARYL-INGENOL | LEO LABORATORIES LIMITED (IE) | 2014-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150175622-A1 | 3-O-HETEROARYL-INGENOL | VDR, RXRA, PPARG | NPC1 582/4885RAB9A 2588/4885KDR 2595/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.