Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 6/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 3/20 | 0.33 |
| ▸ | CA9 | Q16790 | 3/20 | 0.33 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.32 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL130163 | 0.83 | DGAT1 (0.40) | DGAT1KDM4EALDH1A1TSHRMAPK1 | |
| SCHEMBL23123688 | 0.83 | CYP3A4 (0.37) | DGAT1KDM4EALDH1A1HTTNPSR1 | |
| SCHEMBL23122981 | 0.81 | DGAT1 (0.35) | DGAT1KDM4EALDH1A1HTTTSHR | |
| SCHEMBL14972966 | 0.79 | LMNA (0.40) | KDM4EALDH1A1TSHRNPC1RAB9A | |
| SCHEMBL128737 | 0.77 | NPC1 (0.34) | DGAT1KDM4EALDH1A1TSHRMAPK1 | |
| SCHEMBL15564525 | 0.77 | ALDH1A1 (0.46) | DGAT1KDM4EALDH1A1HTTTSHR | |
| SCHEMBL16008683 | 0.76 | ALDH1A1 (0.36) | DGAT1KDM4EALDH1A1HTTTSHR | |
| SCHEMBL24736389 | 0.76 | DGAT1 (0.44) | DGAT1KDM4EALDH1A1CYP1A2 | |
| SCHEMBL25911876 | 0.76 | DGAT1 (0.37) | DGAT1KDM4ECYP1A2KLKB1NPC1 | |
| SCHEMBL25755852 | 0.75 | TSHR (0.41) | DGAT1KDM4EALDH1A1TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2882710-A1 | CARBOXAMIDE OR SULFONAMIDE SUBSTITUTED NITROGEN-CONTAINING 5-MEMBERED HETEROCYCLES AS MODULATORS FOR THE ORPHAN NUCLEAR RECEPTOR ROR GAMMA | Phenex Pharmaceuticals AG (DE) | 2015-06-17 | — | — | EP | disclosed |
| WO-2014023367-A1 | CARBOXAMIDE OR SULFONAMIDE SUBSTITUTED NITROGEN-CONTAINING 5-MEMBERED HETEROCYCLES AS MODULATORS FOR THE ORPHAN NUCLEAR RECEPTOR ROR GAMMA | PHENEX PHARMACEUTICALS AG (DE) | 2014-02-13 | — | — | WO | disclosed |