Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | XBP1 | P17861 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.49 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.49 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.47 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.47 |
| ▸ | P2RX2 | Q9UBL9 | 2/20 | 0.47 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16998525 | 1.00 | ALDH1A1 (0.53) | ALDH1A1XBP1HTTMAOAMAOB | |
| SCHEMBL18328139 | 0.91 | MAOA (0.61) | ALDH1A1XBP1HTTMAOAMAOB | |
| SCHEMBL14025468 | 0.86 | TAS2R14 (0.60) | ALDH1A1XBP1HTTTAS2R14 | |
| SCHEMBL14025466 | 0.83 | TAS2R14 (0.50) | ALDH1A1XBP1HTTRAB9ATAS2R14 | |
| SCHEMBL12124861 | 0.83 | HTT (0.57) | ALDH1A1XBP1HTTMAOAMAOB | |
| SCHEMBL12124859 | 0.83 | HTT (0.57) | ALDH1A1XBP1HTTMAOAMAOB | |
| SCHEMBL12124857 | 0.83 | HTT (0.57) | ALDH1A1XBP1HTTMAOAMAOB | |
| SCHEMBL9493448 | 0.80 | SLC18A3 (0.56) | ALDH1A1XBP1HTTRAB9ATAS2R14 | |
| SCHEMBL13209092 | 0.80 | ALDH1A1 (0.58) | ALDH1A1XBP1HTTMAOAMAOB | |
| SCHEMBL13209087 | 0.79 | HTT (0.61) | ALDH1A1XBP1HTTMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2882740-B1 | IAP ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2017-03-01 | — | — | EP | disclosed |
| EP-2882740-B1 | IAP ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2017-03-01 | — | — | EP | disclosed |
| US-9453048-B2 | IAP antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-09-27 | — | — | US | disclosed |
| US-9453048-B2 | IAP antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-09-27 | — | — | US | disclosed |
| US-20150225452-A1 | IAP ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY | 2015-08-13 | — | — | US | disclosed |
| US-20150225452-A1 | IAP ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY | 2015-08-13 | — | — | US | disclosed |
| EP-2882740-A1 | IAP ANTAGONISTS | Bristol-Myers Squibb Company (US) | 2015-06-17 | — | — | EP | disclosed |
| WO-2014025759-A1 | IAP ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-02-13 | — | — | WO | disclosed |
| WO-2014025759-A1 | IAP ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-02-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150225452-A1 | IAP ANTAGONISTS | XIAP, API5, BIRC5 | ALDH1A1 3456/4885XBP1 334/4885HTT 3265/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.