Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | CCR2 | P41597 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29878478 | 0.79 | KMO (0.46) | KMO | |
| SCHEMBL8167996 | 0.79 | KMO (0.46) | KMO | |
| SCHEMBL22121890 | 0.76 | KMO (0.51) | KMO | |
| SCHEMBL10323271 | 0.75 | KMO (0.45) | KMO | |
| SCHEMBL15141399 | 0.73 | DRD2 (0.41) | MAPK14KCNH2 | |
| SCHEMBL25147466 | 0.71 | PIK3CD (0.41) | KMODYRK1A | |
| SCHEMBL1556579 | 0.71 | HRH4 (0.42) | KMO | |
| SCHEMBL6056595 | 0.69 | RET (0.36) | — | |
| SCHEMBL15448221 | 0.68 | MAPK11 (0.33) | MAPK14KCNH2 | |
| SCHEMBL17886515 | 0.68 | DRD4 (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2303859-A2 | ARYL GPR119 AGONISTS AND USES THEREOF | Metabolex Inc. (US) | 2011-04-06 | — | — | EP | disclosed |
| WO-2010008739-A2 | ARYL GPR119 AGONISTS AND USES THEREOF | METABOLEX, INC. (US) | 2010-01-21 | — | — | WO | disclosed |