Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.53 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.44 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.44 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.44 |
| ▸ | EEF2K | O00418 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4405257 | 0.87 | OPRM1 (0.42) | OPRM1PAK1L3MBTL1POLBGAA | |
| SCHEMBL2637133 | 0.85 | OPRM1 (0.50) | OPRM1PAK1L3MBTL1POLBNPC1 | |
| SCHEMBL2637135 | 0.84 | OPRM1 (0.49) | OPRM1PAK1L3MBTL1POLBNPC1 | |
| SCHEMBL25232523 | 0.83 | KMT2A (0.47) | OPRM1PAK1POLBGAAKMT2A | |
| SCHEMBL3851155 | 0.82 | KDM4E (0.59) | L3MBTL1POLBNPC1RAB9AGAA | |
| SCHEMBL15565385 | 0.81 | ALDH1A1 (0.56) | OPRM1L3MBTL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL18115905 | 0.80 | BTK (0.39) | OPRM1PAK1L3MBTL1GAALMNA | |
| SCHEMBL6928194 | 0.79 | ACKR3 (0.49) | OPRM1PAK1L3MBTL1POLBNPC1 | |
| SCHEMBL16422849 | 0.79 | KMT2A (0.51) | NPC1GAAKMT2AALDH1A1MAPT | |
| SCHEMBL18115998 | 0.79 | THRB (0.46) | POLBNPC1RAB9ASMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2882722-A1 | QUINOXALINE DERIVATIVES AS GPR6 MODULATORS | Envoy Therapeutics Inc. (US) | 2015-06-17 | — | — | EP | disclosed |
| WO-2014028479-A1 | QUINOXALINE DERIVATIVES AS GPR6 MODULATORS | ENVOY THERAPEUTICS, INC. (US) | 2014-02-20 | — | — | WO | disclosed |