Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.39 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MPO | P05164 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | TDO2 | P48775 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1555816 | 0.76 | CES2 (0.51) | KMT2AALDH1A1MEN1KDM4ECYP1A2 | |
| SCHEMBL7977917 | 0.74 | KMT2A (0.41) | KMT2AALDH1A1NAMPTIDO1TDO2 | |
| SCHEMBL30368283 | 0.73 | KMT2A (0.40) | KMT2ANAMPTIDO1TDO2 | |
| SCHEMBL1555200 | 0.72 | KMT2A (0.35) | KMT2AMEN1HSD17B10SMN1; SMN2IDO1 | |
| SCHEMBL1554836 | 0.72 | CES2 (0.49) | KMT2AALDH1A1MEN1KDM4EGAA | |
| SCHEMBL9255635 | 0.69 | KMT2A (0.43) | KMT2AALDH1A1NAMPTSMN1; SMN2IDO1 | |
| SCHEMBL2783342 | 0.69 | NAPRT (0.65) | KMT2ANAPRTALDH1A1MEN1KDM4E | |
| SCHEMBL5752803 | 0.67 | KMT2A (0.47) | KMT2AALDH1A1NAMPTIDO1TDO2 | |
| SCHEMBL8866018 | 0.67 | HDAC8 (0.40) | KMT2A | |
| SCHEMBL9459853 | 0.66 | MAPT (0.53) | KMT2ANAPRTALDH1A1MEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488533-A1 | IMIDAZOTHIAZOLE-CHALCONE DERIVATIVES AS POTENTIAL ANTICANCER AGENTS AND PROCESS FOR THE PREPARATION THEREOF | Council of Scientific & Industrial Research (IN) | 2012-08-22 | — | — | EP | claimed |
| WO-2011045646-A1 | IMIDAZOTHIAZOLE-CHALCONE DERIVATIVES AS POTENTIAL ANTICANCER AGENTS AND PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2011-04-21 | — | — | WO | claimed |