Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PFKFB3 | Q16875 | 4/20 | 0.53 |
| ▸ | CYP1A1 | P04798 | 9/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 9/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 9/20 | 0.47 |
| ▸ | CYP1B1 | Q16678 | 9/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | NPY1R | P25929 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | NPY2R | P49146 | 1/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1555817 | 0.77 | CYP1B1 (0.59) | CYP1A1CYP1A2CYP2D6CYP1B1MAPT | |
| SCHEMBL2522174 | 0.75 | HCAR2 (0.48) | SMN1; SMN2MAPK1HDAC6KMT2A | |
| SCHEMBL2522171 | 0.75 | HCAR2 (0.48) | SMN1; SMN2MAPK1HDAC6KMT2A | |
| SCHEMBL6997673 | 0.74 | HTT (0.67) | PFKFB3CYP1A1CYP1A2CYP2D6CYP1B1 | |
| SCHEMBL6997670 | 0.74 | HTT (0.67) | PFKFB3CYP1A1CYP1A2CYP2D6CYP1B1 | |
| SCHEMBL4572963 | 0.74 | GLA (0.38) | CYP1A2HTTMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL18985284 | 0.74 | CCNC (0.41) | HTTMAPTSMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL4572964 | 0.74 | GLA (0.38) | CYP1A2HTTMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL6934856 | 0.73 | CYP1B1 (0.70) | PFKFB3CYP1A1CYP1A2CYP2D6CYP1B1 | |
| SCHEMBL6934854 | 0.73 | CYP1B1 (0.70) | PFKFB3CYP1A1CYP1A2CYP2D6CYP1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488533-A1 | IMIDAZOTHIAZOLE-CHALCONE DERIVATIVES AS POTENTIAL ANTICANCER AGENTS AND PROCESS FOR THE PREPARATION THEREOF | Council of Scientific & Industrial Research (IN) | 2012-08-22 | — | — | EP | claimed |
| WO-2011045646-A1 | IMIDAZOTHIAZOLE-CHALCONE DERIVATIVES AS POTENTIAL ANTICANCER AGENTS AND PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2011-04-21 | — | — | WO | claimed |