Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.67 |
| ▸ | PFKFB3 | Q16875 | 2/20 | 0.58 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.56 |
| ▸ | CYP1A1 | P04798 | 9/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 9/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 9/20 | 0.55 |
| ▸ | CYP1B1 | Q16678 | 9/20 | 0.55 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | NPY1R | P25929 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | NPY2R | P49146 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 2/20 | 0.52 |
| ▸ | ATM | Q13315 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6997673 | 1.00 | HTT (0.67) | HTTPFKFB3NAPRTCYP1A1CYP1A2 | |
| SCHEMBL27687985 | 0.86 | HTT (0.63) | HTTPFKFB3NAPRTCYP1A1CYP1A2 | |
| SCHEMBL6934854 | 0.84 | CYP1B1 (0.70) | HTTPFKFB3CYP1A1CYP1A2CYP2D6 | |
| SCHEMBL6934856 | 0.84 | CYP1B1 (0.70) | HTTPFKFB3CYP1A1CYP1A2CYP2D6 | |
| SCHEMBL8501319 | 0.82 | ALDH1A1 (0.58) | HTTPFKFB3NAPRTCYP1A1CYP1A2 | |
| SCHEMBL2999914 | 0.81 | ALDH1A1 (0.55) | HTTPFKFB3NAPRTCYP1A1CYP1A2 | |
| SCHEMBL1863 | 0.81 | HTT (1.00) | HTTCYP1A1CYP1A2CYP2D6CYP1B1 | |
| SCHEMBL11007423 | 0.81 | HTT (0.53) | HTTPFKFB3NAPRTCYP1A1CYP1A2 | |
| SCHEMBL2999911 | 0.81 | ALDH1A1 (0.55) | HTTPFKFB3NAPRTCYP1A1CYP1A2 | |
| SCHEMBL11005951 | 0.81 | HTT (0.53) | HTTPFKFB3NAPRTCYP1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0921119-B1 | Pyrrole derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-07-02 | — | — | EP | disclosed |
| US-6114360-A | Pyrrole compounds | ADIR ET COMPAGNIE (FR) | 2000-09-05 | — | — | US | disclosed |
| US-6063804-A | Pyrrole compounds | ADIR ET COMPAGNIE (FR) | 2000-05-16 | — | — | US | disclosed |
| EP-0921119-A1 | Pyrrole derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1999-06-09 | — | — | EP | disclosed |