Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1B1 | Q16678 | 11/20 | 0.70 |
| ▸ | CYP1A1 | P04798 | 10/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 10/20 | 0.70 |
| ▸ | CYP2D6 | P10635 | 9/20 | 0.70 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.69 |
| ▸ | JUN | P05412 | 1/20 | 0.67 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.67 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | TNFRSF1A | P19438 | 2/20 | 0.59 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | BCHE | P06276 | 1/20 | 0.59 |
| ▸ | ACHE | P22303 | 1/20 | 0.59 |
| ▸ | MAOB | P27338 | 1/20 | 0.59 |
| ▸ | RECQL | P46063 | 1/20 | 0.59 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.59 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | F3 | P13726 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6934854 | 1.00 | CYP1B1 (0.70) | CYP1B1CYP1A1CYP1A2CYP2D6PFKFB3 | |
| SCHEMBL363680 | 0.90 | CYP1B1 (0.75) | CYP1B1CYP1A1CYP1A2CYP2D6PFKFB3 | |
| SCHEMBL10033954 | 0.90 | CYP1B1 (0.75) | CYP1B1CYP1A1CYP1A2CYP2D6PFKFB3 | |
| SCHEMBL1390167 | 0.90 | CYP1B1 (0.75) | CYP1B1CYP1A1CYP1A2CYP2D6PFKFB3 | |
| SCHEMBL5593108 | 0.90 | CYP1B1 (0.75) | CYP1B1CYP1A1CYP1A2CYP2D6PFKFB3 | |
| SCHEMBL1603994 | 0.89 | F3 (0.76) | CYP1B1CYP1A1CYP1A2NFKB1MAPT | |
| SCHEMBL28700731 | 0.89 | F3 (0.76) | CYP1B1CYP1A1CYP1A2NFKB1MAPT | |
| SCHEMBL1603995 | 0.89 | F3 (0.76) | CYP1B1CYP1A1CYP1A2CYP2D6PFKFB3 | |
| SCHEMBL31436374 | 0.89 | F3 (0.76) | CYP1B1CYP1A1CYP1A2CYP2D6PFKFB3 | |
| SCHEMBL6934335 | 0.87 | CYP1B1 (0.70) | CYP1B1CYP1A1CYP1A2CYP2D6JUN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115403522-A | Biphenyl quinoline skeleton compound with C2 axis chirality, chiral isomer thereof, preparation method and application thereof | 中国科学院成都有机化学有限公司 | 2022-11-29 | — | — | CN | disclosed |
| US-6649604-B2 | Analgesics; antidiabetic agents; antiinflamamtory agents | AMGEN INC. | 2003-11-18 | — | — | US | disclosed |
| US-20030073704-A1 | Substituted pyridone compounds and methods of use | AMGEN INC. | 2003-04-17 | — | — | US | disclosed |
| US-6420385-B1 | INFLAMMATORY, PAIN AND DIABETES DISEASES, | AMGEN INC. | 2002-07-16 | — | — | US | disclosed |
| US-6096753-A | Substituted pyrimidinone and pyridone compounds and methods of use | AMGEN INC. (US) | 2000-08-01 | — | — | US | disclosed |
| EP-0948496-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDONE COMPOUNDS AND METHODS OF USE | Amgen inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998024780-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDINONE COMPOUNDS AND THEIR USE | AMGEN INC. (US) | 1998-06-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030073704-A1 | Substituted pyridone compounds and methods of use | IL6, IL1B, IL1A | CYP1B1 115/4885CYP1A1 201/4885CYP1A2 276/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.