Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK3 | O14649 | 3/20 | 0.38 |
| ▸ | KCNK9 | Q9NPC2 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
| ▸ | RXRB | P28702 | 1/20 | 0.37 |
| ▸ | RXRG | P48443 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | PPARD | Q03181 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL646644 | 0.80 | KCNK3 (0.39) | KCNK3KCNK9GAARXRARXRB | |
| SCHEMBL27624241 | 0.79 | KCNK3 (0.44) | KCNK3KCNK9GAARXRARXRB | |
| SCHEMBL27643692 | 0.79 | CYP2D6 (0.36) | KCNK3KCNK9GAARXRARXRB | |
| SCHEMBL6442565 | 0.79 | MAOA (0.37) | ALDH1A1SLC6A4L3MBTL1MAOAMAOB | |
| SCHEMBL27676041 | 0.78 | SLC6A2 (0.39) | KCNK3KCNK9GAARXRARXRB | |
| SCHEMBL169082 | 0.78 | CA1 (0.46) | GAAALDH1A1L3MBTL1POLBNPSR1 | |
| SCHEMBL6445833 | 0.78 | EPAS1 (0.34) | CYP11B1CYP11B2FFAR4 | |
| SCHEMBL1047239 | 0.77 | KCNK3 (0.47) | KCNK3KCNK9GAARXRARXRB | |
| SCHEMBL7339549 | 0.77 | KCNK3 (0.40) | KCNK3KCNK9GAARXRARXRB | |
| SCHEMBL27703298 | 0.77 | KCNK3 (0.43) | KCNK3KCNK9GAARXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1749002-A1 | PYRROLE OR IMIDAZOLE AMIDES FOR TREATING OBESITY | F.HOFFMANN-LA ROCHE AG (CH) | 2007-02-07 | — | — | EP | disclosed |
| WO-2005108393-A1 | PYRROLE OR IMIDAZOLE AMIDES FOR TREATING OBESITY | F. HOFFMANN-LA ROCHE AG (CH) | 2005-11-17 | — | — | WO | disclosed |