Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.33 |
| ▸ | KDM5A | P29375 | 2/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 3/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | MMP12 | P39900 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4647626 | 0.76 | KDM5A (0.40) | KDM4EKDM5AKDM5BCYP1A2PDE3B | |
| SCHEMBL4966514 | 0.75 | BRS3 (0.34) | ALDH1A1KDM4EKDM5AKDM5BCYP1A2 | |
| SCHEMBL6205311 | 0.72 | HNF4A (0.45) | ALDH1A1KDM4EKDM5AKDM5BSMN1; SMN2 | |
| SCHEMBL6902769 | 0.72 | CYP1A2 (0.42) | ALDH1A1KDM4ECYP1A2HSD17B10TDP1 | |
| SCHEMBL23537975 | 0.72 | HCAR2 (0.39) | ALDH1A1KDM4EKDM5AKDM5BGAA | |
| SCHEMBL2434357 | 0.69 | KDM4E (0.39) | ALDH1A1KDM4EKDM5BSMN1; SMN2RXFP1 | |
| SCHEMBL4146790 | 0.69 | KDM4E (0.47) | ALDH1A1KDM4ECYP1A2GAASMN1; SMN2 | |
| SCHEMBL6473197 | 0.68 | KDM4E (0.47) | ALDH1A1KDM4ERXFP1MMP1MMP2 | |
| SCHEMBL16880866 | 0.67 | KMT2A (0.53) | ALDH1A1KDM4ECYP1A2GAASMN1; SMN2 | |
| SCHEMBL14694284 | 0.66 | UPP1 (0.45) | ALDH1A1KDM4ECYP1A2GAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014025651-A1 | CHROMAN DERIVATIVES AS TRPM8 INHIBITORS | AMGEN INC. (US) | 2014-02-13 | — | — | WO | disclosed |