Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRS3 | P32247 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.33 |
| ▸ | GAA | P10253 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | UCHL1 | P09936 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | KDM5A | P29375 | 1/20 | 0.31 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.31 |
| ▸ | RXRB | P28702 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4647626 | 0.77 | KDM5A (0.40) | CYP1A2KDM4EKDM5AKDM5B | |
| SCHEMBL20606945 | 0.76 | MTNR1A (0.34) | KDM4EALDH1A1GAASMN1; SMN2RXFP1 | |
| SCHEMBL15567932 | 0.75 | ALDH1A1 (0.34) | CYP1A2KDM4EALDH1A1GAASMN1; SMN2 | |
| SCHEMBL6205311 | 0.74 | HNF4A (0.45) | KDM4EALDH1A1SMN1; SMN2ALOX15KDM5A | |
| SCHEMBL23537975 | 0.73 | HCAR2 (0.39) | KDM4EALDH1A1GAASMN1; SMN2RXFP1 | |
| SCHEMBL4433471 | 0.72 | KDM4E (0.45) | BRS3CYP1A2KDM4EALDH1A1GAA | |
| SCHEMBL4146790 | 0.70 | KDM4E (0.47) | CYP1A2KDM4EALDH1A1GAASMN1; SMN2 | |
| SCHEMBL6473197 | 0.69 | KDM4E (0.47) | KDM4EALDH1A1RXFP1HSD17B10POLB | |
| SCHEMBL16880866 | 0.68 | KMT2A (0.53) | CYP1A2KDM4EALDH1A1GAASMN1; SMN2 | |
| SCHEMBL14694284 | 0.67 | UPP1 (0.45) | CYP1A2KDM4EALDH1A1GAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1954693-A1 | BETA-SECRETASE MODULATORS AND METHODS OF USE | Amgen Inc. (US) | 2008-08-13 | — | — | EP | disclosed |
| WO-2007062007-A1 | BETA-SECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2007-05-31 | — | — | WO | disclosed |