Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.45 |
| ▸ | LCK | P06239 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15569439 | 0.82 | BRD4 (0.42) | BRD4LCKGAAIGF1RKDM4E | |
| SCHEMBL15569873 | 0.79 | BRD4 (0.38) | BRD4LCKGAAKDM4EALDH1A1 | |
| SCHEMBL15568577 | 0.79 | BRD4 (0.45) | BRD4LCKGAAKDM4EALDH1A1 | |
| SCHEMBL15569789 | 0.76 | TUBB4A (0.41) | BRD4LCKMKNK1 | |
| SCHEMBL15568495 | 0.70 | BRD4 (0.39) | BRD4GAAKDM4EMAPTHTT | |
| SCHEMBL15568531 | 0.66 | ALDH1A1 (0.45) | BRD4KDM4EALDH1A1HSD17B10MAPT | |
| SCHEMBL4191231 | 0.66 | BRD4 (0.42) | BRD4MAPTMKNK1 | |
| SCHEMBL30951387 | 0.64 | PLK4 (0.36) | ALDH1A1HTTMKNK1 | |
| SCHEMBL15568576 | 0.63 | SIRT5 (0.44) | BRD4GAAKDM4EALDH1A1HSD17B10 | |
| SCHEMBL30663508 | 0.62 | BRD4 (1.00) | BRD4LCKGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2885299-A1 | INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A | AbbVie Deutschland GmbH & Co KG (DE) | 2015-06-24 | — | — | EP | claimed |
| WO-2014027078-A1 | INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A | AbbVie Deutschland GmbH & Co. KG (DE) | 2014-02-20 | — | — | WO | claimed |
| EP-2885299-A1 | INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A | AbbVie Deutschland GmbH & Co KG (DE) | 2015-06-24 | — | — | EP | disclosed |
| WO-2014027078-A1 | INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A | AbbVie Deutschland GmbH & Co. KG (DE) | 2014-02-20 | — | — | WO | disclosed |